Maternal intake of docosahexaenoic acid decreased febrile seizure sensitivity by increasing estrogen synthesis in offspring
Maternal intake of docosahexaenoic acid decreased febrile seizure sensitivity by increasing estrogen synthesis in offspring
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DOI：
10.1016/j.yebeh.2021.108038
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发表时间：
2021-05-27
影响因子：
2.6
通讯作者：
Ishihara, Yasuhiro
中科院分区：
文献类型：
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作者：
Kawano, Shinji;Itoh, Kouichi;Ishihara, Yasuhiro
热性惊厥是儿童的惊厥，是由体温突然升高引起的。它们有时是反复发作的，癫痫发作越多，长大后患癫痫和精神疾病的风险就越高。预防热性惊厥被认为是保护儿童未来健康的有效对策之一;然而，从后代健康方面来看，发育阶段的药物预防并不现实。二十二碳六烯酸（DHA）是一种重要的营养素，尤其是在怀孕和儿童时期，据报道可以抑制多种类型的癫痫。本研究的目的是检查在怀孕期间和婴儿期摄入DHA对小鼠热性惊厥的影响。我们使用热室在10至11日龄的后代中诱导热性惊厥。在怀孕和婴儿期摄入DHA会显著增加后代大脑中DHA的含量。虽然DHA对癫痫发作的严重程度没有影响，但DHA显著延长了癫痫发作的潜伏期，并增加了首次癫痫发作时的体温，表明母亲摄入DHA降低了热性癫痫发作的敏感性。脑雌激素水平显着增加DHA的摄入量和管理的抑制剂细胞色素P450芳香化酶，这是一种限速酶雌激素合成，明显降低癫痫发作潜伏期和体温在第一次发作发生。综上所述，DHA可以降低由于脑雌激素含量增加而引起的热性惊厥的易感性。孕期和婴儿期摄入DHA，对保护婴儿不发生癫痫发作和保持生长后的健康有重要意义。(c)2021爱思唯尔公司All rights reserved.
Febrile seizures, which are convulsion in children, are caused by an abrupt increase in body temperature. They are sometimes recurrent, and the more seizures are triggered, the higher the risk of epilepsy and psychiatric disorders increase after growing up. Prevention of febrile seizure is considered to be one of the effective countermeasures in protecting the future health of children; however, pharmacological prevention in the developmental stage is not realistic from the health aspects of the offspring. Docosahexaenoic acid (DHA) is an important nutrient especially during pregnancy and childhood and is reported to suppress several types of epilepsy. The purpose of this study was to examine the effect of DHA intake during pregnancy and infancy on febrile seizures in mice. We used a heat chamber for febrile seizure induction in offspring at the age of from 10 to 11 days old. Intake of DHA during pregnancy and infancy significantly increased the amount of DHA in the brain of offspring. Although DHA had no effect on seizure severity, DHA significantly prolonged the seizure latency and increased body temperature at which the first seizure occurred, indicating that maternal DHA intake decreases febrile seizure sensitivity. Brain estrogen levels significantly increased by DHA intake and administration of an inhibitor for cytochrome P450 aromatase, which is a rate-limiting enzyme for estrogen synthesis, clearly decreased seizure latency and body temperature at which the first seizure occurred. Taken together, DHA could reduce susceptibility to febrile seizures owing to increases in brain estrogen contents. DHA intake during pregnancy and infancy is of significance in protecting infant from seizures as well as conserving health after growth. (c) 2021 Elsevier Inc. All rights reserved.