Age-dependent cardiovascular effects of sepsis in a murine model of cecal ligation and puncture: implications for the design of interventional studies.
Age-dependent cardiovascular effects of sepsis in a murine model of cecal ligation and puncture: implications for the design of interventional studies.
复制标题
盲肠结扎和穿刺小鼠模型中败血症的年龄依赖性心血管影响：对干预研究设计的影响。
DOI：
10.1152/ajpheart.00528.2018
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Pacher,Pal
中科院分区：
文献类型：
--
作者：
Ungvari,Zoltan;Yabluchanskiy,Andriy;Hasko,Gyorgy;Pacher,Pal
Sepsis is more prevalent in the elderly population, with increased incidence and mortality occurring in patients aged 65 yr or older (Fig. 1)(6). Previous preclinical studies in murine models of cecal ligation and puncture-induced septic shock have demonstrated that aging significantly increases the severity of sepsis and exacerbates the development of multiple organ dysfunction syndrome (involving cardiovascular collapse) by multifaceted mechanisms, which include dysregulation of the innate immune response and adaptive immune response, excessive pulmonary and systemic inflammation, increased coagulation, proinflammatory alterations of the adipose tissue, gut apoptosis, and an age-related worsening of microvascular endothelial dysfunction and exacerbation of oxidative stress (1, 7–9). In an interesting study recently published in the American
