Contributions of spectral frequency analyses to the study of P50 ERP amplitude and suppression in bipolar disorder with or without a history of psychosis
Contributions of spectral frequency analyses to the study of P50 ERP amplitude and suppression in bipolar disorder with or without a history of psychosis
复制标题
DOI：
10.1111/j.1399-5618.2008.00622.x
复制
发表时间：
2008-11-01
影响因子：
5.4
通讯作者：
Hetrick, William P.
中科院分区：
文献类型：
--
作者：
Carroll, Christine A.;Kieffaber, Paul D.;Hetrick, William P.
目的：本研究调查事件相关脑电位（ERP）指数的听觉处理和感觉门控双相情感障碍和亚组的双相患者有或没有精神病史使用P50双击程序。听觉诱发的活动在两个离散的频带也进行了探讨，以区分感觉登记和选择性attention deficits.Methods：31个人与双相情感障碍和28个非精神对照进行了比较，使用双击程序的听觉处理的ERP指数。除了传统的P50 ERP峰值提取技术，定量频率分析被应用于ERP数据，以隔离与感觉记录相关的信息处理阶段（20-50 Hz;伽马波段）和选择性注意（0-20 Hz;低频带）。与非精神病对照组相比，双相情感障碍患者在传统的P50峰值拾取和低频反应分析中表现出降低的S1反应幅度。双极亚组效应表明，P50峰值和低频分析的衰减S1幅度主要归因于无精神病史的患者。分析了在双相电刺激期间引起的脑电诱发反应的不同频带，Click程序允许进一步说明有或无病史的双相情感障碍患者的听觉感觉处理和门控缺陷的性质精神病在低频带观察到的S1效应表明双相情感障碍患者存在选择性注意力缺陷，尤其是那些没有精神病史的患者，这可能反映了选择性注意突出刺激的能力下降，而不是抑制性感觉过程的损害。
Objective: The present study investigated event-related brain potential (ERP) indices of auditory processing and sensory gating in bipolar disorder and subgroups of bipolar patients with or without a history of psychosis using the P50 dual-click procedure. Auditory-evoked activity in two discrete frequency bands also was explored to distinguish between sensory registration and selective attention deficits.Methods: Thirty-one individuals with bipolar disorder and 28 non-psychiatric controls were compared on ERP indices of auditory processing using a dual-click procedure. In addition to conventional P50 ERP peak-picking techniques, quantitative frequency analyses were applied to the ERP data to isolate stages of information processing associated with sensory registration (20-50 Hz; gamma band) and selective attention (0-20 Hz; low-frequency band).Results: Compared to the non-psychiatric control group, patients with bipolar disorder exhibited reduced S1 response magnitudes for the conventional P50 peak-picking and low-frequency response analyses. A bipolar subgroup effect suggested that the attenuated S1 magnitudes from the P50 peak- picking and low-frequency analyses were largely attributable to patients without a history of psychosis.Conclusions: The analysis of distinct frequency bands of the auditory-evoked response elicited during the dual-click procedure allowed further specification of the nature of auditory sensory processing and gating deficits in bipolar disorder with or without a history of psychosis. The observed S1 effects in the low-frequency band suggest selective attention deficits in bipolar patients, especially those patients without a history of psychosis, which may reflect a diminished capacity to selectively attend to salient stimuli as opposed to impairments of inhibitory sensory processes.