Labile protein reserves and protein turnover.
Labile protein reserves and protein turnover.
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不稳定的蛋白质储备和蛋白质周转。
DOI：
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发表时间：
1977
影响因子：
3.5
通讯作者：
N. J. Benevenga
中科院分区：
文献类型：
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作者：
R. W. Swick;N. J. Benevenga
不稳定蛋白质储备的概念是基于在饮食供应突然变化后，氮排泄率建立在新的平衡上的相对缓慢的基础上。综述的证据表明，这种氮的大部分来自或沉积在骨骼肌蛋白质中。大型动物(人和猪)体内总蛋白质的合成和降解速度很快，并与产热量有关。骨骼肌中蛋白质合成的速度大大超过了生长速度，并且对营养状况很敏感。这一速度超过了摄取足够食物时的降解速度，从而积累了组织蛋白质，但在缺乏条件下，它下降到低于降解速度。在后一种状态下，骨骼肌的蛋白质为能量或其他更重要的蛋白质的合成提供氨基酸，例如哺乳期间的乳蛋白。因此，我们得出结论，不稳定的蛋白质储备是蛋白质正常、动态代谢的产物。
The concept of a labile protein reserve is based on the relatively slow establishment of a new equilibrium in the rate of nitrogen excretion after an abrupt change in dietary supply. The evidence reviewed shows that a majority of this nitrogen is derived from or deposited in skeletal muscle proteins. The rates of synthesis and degradation of total body protein are rapid in large animals (man and swine) and are correlated with heat production. The rate of protein synthesis in skeletal muscle greatly exceeds the rate of growth and is sensitive to nutritional status. The rate exceeds the rate of degradation in response to the ingestion of an adequate diet so that tissue proteins are accumulated, but it decreases below the rate of degradation under conditions of deprivation. In this latter state, proteins of skeletal muscle supply amino acids for energy or for the synthesis of other more essential proteins, e.g., milk proteins during lactation. Thus, we conclude that the labile protein reserve is a product of the normal, dynamic metabolism of protein.