Occupational use of high-level disinfectants and asthma incidence in early- to mid-career female nurses: a prospective cohort study.
Occupational use of high-level disinfectants and asthma incidence in early- to mid-career female nurses: a prospective cohort study.
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DOI：
10.1136/oemed-2020-106793
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发表时间：
2021-04
影响因子：
4.9
通讯作者：
Camargo CA Jr
中科院分区：
文献类型：
--
作者：
Dumas O;Gaskins AJ;Boggs KM;Henn SA;Le Moual N;Varraso R;Chavarro JE;Camargo CA Jr
卫生保健工作者职业性使用消毒剂与哮喘有关。然而，大多数研究都是横向研究，纵向研究并不完全一致。为了限制健康工人的影响，重要的是在职业生涯的早期到中期工人中进行研究。我们在一个大的早期到中期职业女性护士队列中调查了使用消毒剂和哮喘发病率之间的前瞻性关联。护士健康研究3是一项正在进行的、前瞻性的、基于互联网的美国和加拿大女护士队列研究（2010年至今）。分析包括17，280名参与者，他们在进入研究时没有哮喘史（平均年龄：34岁），并且完成了≥1次随访问卷（每6个月发送一次）。采用问卷调查的方法对职业性高水平消毒剂使用情况进行评价。我们研究了HLD使用与哮喘发展之间的关系，并对年龄、种族、民族、吸烟状况和体重指数进行了调整。在67，392人年的随访中，391名护士报告了临床医生诊断的哮喘事件。与报告使用HLD ≤5年的护士（89%）相比，使用HLD>5年的护士（11%）发生哮喘的风险增加（校正风险比[95%CI]，1.38 [1.03-1.85]）。在报告使用HLD>5年和目前使用≥2种产品的患者中，哮喘发作风险升高，但无统计学显著性（1.72 [0.88-3.34]）;在使用HLD>5年但目前未使用的女性中，哮喘风险显著升高（1.46 [1.00-2.12]）。职业使用高水平消毒剂与职业生涯早期至中期护士哮喘发病率增加前瞻性相关。
Occupational use of disinfectants among healthcare workers has been associated with asthma. However, most studies are cross-sectional and longitudinal studies are not entirely consistent. To limit the healthy worker effect, it is important to conduct studies among early to mid-career workers. We investigated the prospective association between use of disinfectants and asthma incidence in a large cohort of early to mid-career female nurses. The Nurses’ Health Study 3 is an ongoing, prospective, internet-based cohort of female nurses in the United States and Canada (2010-present). Analyses included 17,280 participants without history of asthma at study entry (mean age: 34 years) and who had completed ≥1 follow-up questionnaire (sent every 6 months). Occupational use of high-level disinfectants (HLDs) was evaluated by questionnaire. We examined the association between HLD use and asthma development, adjusted for age, race, ethnicity, smoking status, and body mass index. During 67,392 person-years of follow-up, 391 nurses reported incident clinician-diagnosed asthma. Compared to nurses who reported ≤5 years of HLD use (89%), those with >5 years of HLD use (11%) had increased risk of incident asthma (adjusted hazard ratio [95%CI], 1.38 [1.03-1.85]). The risk of incident asthma was elevated but not statistically significant in those reporting >5 years of HLD use and current use of ≥2 products (1.72 [0.88-3.34]); asthma risk was significantly elevated in women with >5 years of HLD use but no current use (1.46 [1.00-2.12]). Occupational use of high-level disinfectants was prospectively associated with increased asthma incidence in early to mid-career nurses.
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影响因子：
3.5
作者：
Dumas, Orianne;Boggs, Krislyn M.;Camargo, Carlos A.
通讯作者：
Camargo, Carlos A.
影响因子：
4.9
作者：
Quinn, Margaret M.;Henneberger, Paul K.
通讯作者：
Henneberger, Paul K.
影响因子：
10
作者：
Ghosh, Rebecca Elisabeth;Cullinan, Paul;Jarvis, Debbie
通讯作者：
Jarvis, Debbie
影响因子：
4.5
作者：
Henn, Scott A.;Boiano, James M.;Steege, Andrea L.
通讯作者：
Steege, Andrea L.
DOI：
10.1093/annhyg/mes083
发表时间：
2013-05
期刊：
The Annals of occupational hygiene
影响因子：
--
作者：
Lillienberg L;Andersson E;Janson C;Dahlman-Höglund A;Forsberg B;Holm M;Glslason T;Jögi R;Omenaas E;Schlünssen V;Sigsgaard T;Svanes C;Torén K
通讯作者：
Torén K