Interaction between FKBP5 polymorphisms and childhood trauma on depressive symptoms in Chinese adolescents: The moderating role of resilience
Interaction between FKBP5 polymorphisms and childhood trauma on depressive symptoms in Chinese adolescents: The moderating role of resilience
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DOI：
10.1016/j.jad.2020.01.051
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发表时间：
2020-04-01
影响因子：
6.6
通讯作者：
Han, Juan
中科院分区：
文献类型：
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作者：
Kang, Chun;Shi, JunXin;Han, Juan
背景：之前关于抑郁症的基因-环境研究已经考察了FKBP5基因与童年创伤之间的相互作用，但结果不一致，且很少有研究关注亚洲青少年。心理弹性可以解释这种不一致。我们研究了 FKBP5 基因与童年创伤对中国青少年抑郁症状的相互作用，并首先探讨了心理弹性在这种关系中的调节作用。 方法：本研究包括从中国湖北省武汉市四所高中随机招募的 942 名参与者（448 名男性，47.6%）。抑郁症状、童年创伤和心理弹性分别通过流行病学研究中心抑郁量表（CES-D）、儿童创伤问卷（CTQ）和康纳-戴维森心理弹性量表（CD-RISC）进行评估。选择三个潜在功能性 FKBP5 多态性进行基因分型。 结果：携带 FKBP5 多态性次要等位基因（rs3800373、rs1360780 和 rs4713916）以及源自这些变体的单倍型的参与者在调整人口特征和复原力后，在童年遭受身体虐待时表现出较高的 CES-D 分数（所有 P < 0.01）。在调整人口特征后，FKBP5 SNP、身体虐待和抑郁症状恢复力的三向相互作用均产生统计学显着性（β = - 0.282 至 - 0.236；所有 P < 0.001）。 局限性：横断面设计、自我报告测量和有限的基因型 FKBP5 多态性。 结论： FKBP5 变异与儿童期身体虐待相结合可能会增加中国人更明显的抑郁症状青少年，而复原力在关联中起着调节作用。未来需要进行研究来检验这些关联中恢复力的确切机制。
Background: Previous gene-environment studies on depression have examined the interaction between FKBP5 gene and childhood trauma, but the results are inconsistent and few studies have focused on Asian adolescents. Psychological resilience may explain for the inconsistency. We examined the interaction between FKBP5 gene and childhood trauma on depressive symptoms in Chinese adolescents, and firstly explored the moderating role of resilience in the relationship.Methods: This study comprised 942 participants (448 males, 47.6%) randomly recruited from four senior schools in Wuhan, Hubei of China. Depressive symptoms, childhood trauma, and resilience were respectively evaluated by the Center for Epidemiological Studies Depression Scale (CES-D), the Childhood Trauma Questionnaire (CTQ) and the Connor-Davidson Resilience Scale (CD-RISC). Three potentially functional FKBP5 polymorphisms were selected for genotyping.Results: Participants carrying minor alleles of FKBP5 polymorphisms (rs3800373, rs1360780, and rs4713916) and a haplotype derived from these variants displayed higher CES-D scores when exposed to childhood physical abuse after adjusting for demographic characteristics and resilience (all P < 0.01). The three-way interactions of FKBP5 SNPs, physical abuse, and resilience on depressive symptoms all yielded statistical significance after adjusting for demographic characteristics (beta = - 0.282 to - 0.236; all P < 0.001).Limitations: Cross-sectional design, self- reported measurements and limited genotyped FKBP5 polymorphisms.Conclusion: FKBP5 variants in combination with childhood physical abuse may increase more pronounced depressive symptoms among Chinese adolescents, while resilience plays a moderating role in the associations. Future research to examine the exact mechanism of resilience in these associations is needed.