Overweight and obesity affect treatment response in major depression
Overweight and obesity affect treatment response in major depression
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DOI：
10.1016/j.biopsych.2006.10.001
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发表时间：
2007-08-15
影响因子：
10.6
通讯作者：
Lucae, Susanne
中科院分区：
文献类型：
--
作者：
Kloiber, Stefan;Ising, Marcus;Lucae, Susanne
背景：流行病学和临床研究表明，重度抑郁障碍(MDD)和肥胖是共病。为了阐明体重对抑郁症病程的影响，除了共病，我们调查了MDD患者的精神病理学、注意力、神经内分泌学、体重变化和治疗反应，具体取决于他们的体重。方法：408名MDD住院患者参加了慕尼黑抗抑郁药物反应特征研究，旨在发现预测临床结果的生物标志物和基因类型。每周监测230名患者的精神病理学和人体测量学参数。在亚样本中，在入院和出院时进行地塞米松-促肾上腺皮质激素释放激素和注意力测试。1,029名诊断为匹配的对照组用于形态计量学比较。结果：MDD患者的体重指数明显高于健康对照组。与体重指数正常的患者(18.5)相比，高BMI患者的临床反应明显较慢，神经内分泌学和注意力改善较少，体重增加也较少
Background: Epidemiologic and clinical studies suggest comorbidity between major depressive disorder (MDD) and obesity. To elucidate the impact of weight on the course of depression beyond comorbidity, we investigated psychopathology, attention, neuroendocrinology, weight change, and treatment response in MDD patients, depending on their weight.Methods: Four hundred eight inpatients with MDD participated in the Munich Antidepressant Response Signature Study, designed to discover biomarkers and genotypes that are predictive for clinical outcome. Psychopathology and anthropometric parameters were monitored weekly in 230 patients. In subsamples, combined dexamethasone-corticotropin-releasing hormone and attention tests were conducted at admission and discharge. One thousand twenty-nine diagnosed matched controls served for morphometric comparisons.Results: Patients with MDD had a significantly higher body mass index (BMI) compared with healthy controls. Patients with high BMI (>= 25) showed a significantly slower clinical response, less improvement in neuroendocrinology and attention, and less weight gain than did patients with normal BMI (18.5