Comparison of leak point pressure methods in an animal model of stress urinary incontinence
Comparison of leak point pressure methods in an animal model of stress urinary incontinence
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DOI：
10.1007/s00192-004-1263-4
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发表时间：
2005-10-01
影响因子：
1.8
通讯作者：
Cannon, TW
中科院分区：
文献类型：
--
作者：
Conway, DA;Kamo, I;Cannon, TW
我们比较了有或没有阴部神经和髂尾骨/耻骨尾骨肌神经横截的大鼠泄漏点压力（LPP）的三种不同测试方法：(1)鼻孔须诱导打喷嚏（sneeze LPP），(2)手动增加腹部压力（Crede LPP），(3)使用垂直倾斜表法增加膀胱内压力（vertical tilt table LPP）。在假手术大鼠中，Crede法和垂直倾斜台法的被动膀胱内压力升高诱导主动尿道关闭机制，导致高LPPs（分别为41.4和35.5 cmH(2)O），神经横断显著降低LPPs。在打喷嚏时，在神经横断的大鼠中观察到渗漏，但在假手术大鼠中没有，这表明打喷嚏可以激活额外的尿道关闭机制。用垂直倾斜台和Crede法测量大鼠打喷嚏或被动膀胱内压升高时的LPP，可用于评估不同应激条件下大鼠的失禁机制。
We compared three different methods of testing leak point pressure (LPP) in rats with or without the pudendal nerves and nerves to the iliococcygeus/pubococcygeus muscles transected: (1) sneeze induced with a whisker in the nostril (sneeze LPP), (2) manually increased abdominal pressure (Crede LPP), and (3) increased intravesical pressure using the vertical tilt table method (vertical tilt table LPP). In sham rats, passive intravesical pressure rises in Crede and vertical tilt table methods induced active urethral closure mechanisms that contributed to high LPPs (41.4 and 35.5 cmH(2)O, respectively), which were significantly reduced by nerve transection. During sneezing, leakage was observed in nerve-transected rats, but not in sham rats, indicating that sneezing can activate an additional urethral closure mechanism. Measuring LPP during sneezing or passive intravesical pressure rises in the vertical tilt table and Crede method seems to be useful for assessing the continence mechanisms under different stress conditions in rats.