Functional Impact of 10 Days of Bed Rest in Healthy Older Adults
Functional Impact of 10 Days of Bed Rest in Healthy Older Adults
复制标题
DOI：
10.1093/gerona/63.10.1076
复制
发表时间：
2008-10-01
影响因子：
5.1
通讯作者：
Evans, William J.
中科院分区：
文献类型：
--
作者：
Kortebein, Patrick;Symons, T. Brock;Evans, William J.
背景资料。许多老年人在住院期间功能下降，卧床休息的有害后果可能是原因之一。本研究报告了10天卧床休息对健康老年人多项功能参数的影响。健康的老年男性和女性(n=11，67+/-5岁)连续卧床休息10天，并按推荐的蛋白质膳食供给量食用无糖饮食。分别于卧床前、卧床后进行下肢力量、有氧能力、体能及体力活动测试。卧床后所有下肢力量指标均显著降低，包括等张伸膝力量(-13.2+/-4.1%，p=.004)和爬楼梯力量(-14+/-4.1%，p=.01)。卧床休息后最大有氧能力降低了12%(p=0.04)。而身体性能的衡量标准(短物理性能电池和现场物理性能测试)没有显著差异。卧床休息后，自愿体力活动减少，不活动时间百分比增加(7.6+/-1.8%，p=0.004)。无内科并发症。在健康的老年人中，10天的卧床休息会导致腿部力量、力量和有氧能力的大幅丧失，并减少体力活动，但对体能没有影响。确定在老年人住院期间或卧床休息期间维持肌肉功能的干预措施应是高度优先的。
Background. Many older individuals decline functionally during hospitalization, and the deleterious consequences of bed rest may be one cause. This study reports on the effect of 10 days of bed rest on multiple functional parameters in healthy older adults.Methods. Healthy older men and women (n = 11, 67 +/- 5 years old) remained on bed rest for 10 days continuously, and consumed a eucaloric diet providing the Recommended Dietary Allowance for protein. Measures of lower extremity strength and power, aerobic capacity and physical performance, as well as physical activity were performed before and after bed rest.Results. All measures of lower extremity strength were significantly lower after bed rest including isotonic knee extensor strength (-13.2 +/- 4.1%, p = .004) and stair-climbing power (-14 +/- 4.1%, p = .01). Maximal aerobic capacity was 12% lower after bed rest (p = .04). whereas measures of physical performance (Short Physical Performance Battery, and a live-item physical performance test) were not significantly different. Voluntary physical activity decreased after bed rest, and the percentage of time spent inactive increased (7.6 +/- 1.8%, p =.004). There were no medical complications.Conclusions. In healthy older adults, 10 days of bed rest results in a substantial loss of lower extremity strength, power, and aerobic capacity, and a reduction in physical activity, but has no effect on physical performance. Identification of interventions to maintain muscle function during hospitalization or periods of bed rest in older adults should be a high priority.