The "emigration, migration, and immigration"of prostate cancer.
The "emigration, migration, and immigration"of prostate cancer.
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DOI：
10.3816/cgc.2005.n.008
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发表时间：
2005-06-01
期刊：
影响因子：
--
通讯作者：
Loberg, Robert
中科院分区：
文献类型：
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作者：
Pienta, Kenneth J;Loberg, Robert
在绝大多数情况下，当癌症扩散到主要器官之外时，它仍然是一种不治之症。迄今为止，大多数癌症研究和治疗设计都集中在针对杀死复制肿瘤细胞的化疗上。很少有人关注靶向原发性肿瘤部位、循环肿瘤细胞或转移性或继发性（靶向）肿瘤部位的微环境以及癌细胞如何在其中移动。为了开发这些靶点，需要更好地理解转移和肿瘤扩散的机制。本文以前列腺癌为模型系统，从迁移到迁移再到迁移的范式，介绍了转移的步骤。
In the vast majority of cases, cancer continues to be an incurable disease when it has spread beyond the primary organ. Most cancer research and therapy design to date has focused on chemotherapy directed at killing the replicating tumor cells. Little attention has been placed on targeting the microenvironments of the primary tumor site, the circulating tumor cells, or the metastatic or secondary (target) tumor site and how cancer cells move among them. To develop these targets, a better understanding of metastasis and the mechanisms underlying the spread of tumors is required. This review describes the steps of metastasis using a paradigm of emigration to migration to immigration, with prostate cancer as a model system.