Effects of n-3 Polyunsaturated Fatty Acids on Left Ventricular Function and Functional Capacity in Patients With Dilated Cardiomyopathy
Effects of n-3 Polyunsaturated Fatty Acids on Left Ventricular Function and Functional Capacity in Patients With Dilated Cardiomyopathy
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DOI：
10.1016/j.jacc.2010.11.017
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发表时间：
2011-02-15
影响因子：
24
通讯作者：
Cas, Livio Dei
中科院分区：
文献类型：
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作者：
Nodari, Savina;Triggiani, Marco;Cas, Livio Dei
目的探讨n-3多不饱和脂肪酸(PUFAs)对非缺血性扩张型心肌病(NICM)所致慢性心力衰竭(心衰)患者左心收缩功能的影响。将133例非缺血性扩张型心肌病患者随机分为n-3多不饱和脂肪酸(PUFAs)2g组和安慰剂对照组。采用超声心动图和心肺运动试验对患者入选前和入选后12个月的心功能和心功能进行前瞻性评估。方法入选NICM所致慢性心衰患者，临床症状轻微，接受循证治疗。结果随机化12个月后，n-3PUFAs组与安慰剂组比较，n-3PUFAs组与安慰剂组比较，差异有统计学意义(P
Objectives This study was designed to test the effects of n-3 polyunsaturated fatty acids (PUFAs) on left ventricular (LV) systolic function in chronic heart failure (HF) due to nonischemic dilated cardiomyopathy (NICM).Background One hundred thirty-three patients with NICM and minimal symptoms on standard therapy were randomized to 2 g of n-3 PUFAs or placebo. LV function and functional capacity were assessed prospectively by echocardiography and cardiopulmonary exercise testing at baseline and at 12 months after randomization.Methods Patients with chronic HF due to NICM and minimal symptoms while receiving evidence-based therapy were enrolled. LV function and functional capacity were assessed prospectively by echocardiography, cardiopulmonary exercise test, and New York Heart Association functional class at baseline and at 12 months after randomization to either 2 g of n-3 PUFAs or placebo.Results At 12 months after randomization, the n-3 PUFAs group and the placebo group differed significantly (p