PREFERENTIAL CYTOTOXICITY OF REOVIRUS FOR CERTAIN TRANSFORMED-CELL LINES
PREFERENTIAL CYTOTOXICITY OF REOVIRUS FOR CERTAIN TRANSFORMED-CELL LINES
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DOI：
10.1007/bf01314776
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发表时间：
1977-01-01
影响因子：
2.7
通讯作者：
YAU, JT
中科院分区：
文献类型：
--
作者：
HASHIRO, G;LOH, PC;YAU, JT
检测了不同哺乳动物来源的多种细胞系对UV光照射的呼肠孤病毒2型（UVR2）或活呼肠孤病毒2型加蛋白质合成抑制剂放线菌酮的细胞毒性（CT）诱导的敏感性。以下细胞组对CT诱导敏感：某些肿瘤细胞和人源自发转化细胞系以及某些鼠源病毒和自发转化细胞系。以下细胞组具有耐药性：正常人二倍体细胞系、次人灵长类动物的原代和连续细胞培养物、原代小鼠细胞、正常大鼠肾细胞和幼仓鼠肾细胞。对CT诱导的敏感性可能与病毒对细胞的吸附无关，也与细胞支持病毒复制的能力无关。
The susceptibility of a variety of cell lines of different mammalian origin to cytotoxic (CT) induction by UV light-irradiated reovirus type 2 (UVR2) or viable reovirus type 2 plus the protein synthesis inhibitor, cycloheximide, was examined. The following groups of cells were susceptible to CT-induction: certain tumor cells and spontaneously transformed cell lines of human origin and certain virally and spontaneously transformed cell lines of murine origin. The following groups of cells were resistant: normal human diploid cell lines, primary and continuous cell cultures of subhuman primates, primary mouse cells, normal rat kidney cells and baby hamster kidney cells. Susceptibility to CT-induction could not be related to the adsorption of virus to cells, nor to the capacity of the cell to support virus replication.