Red blood cell aging and risk of cardiovascular diseases.
Red blood cell aging and risk of cardiovascular diseases.
复制标题
红细胞衰老和心血管疾病的风险。
DOI：
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发表时间：
1998
影响因子：
2.1
通讯作者：
H. Borovetz
中科院分区：
文献类型：
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作者：
M. Kameneva;K. Garrett;M. Watach;H. Borovetz
我们假设，由于每月失血，绝经前女性血液的机械性能上级男性，并使其患心血管疾病的风险低于任何年龄组的男性。比较绝经前妇女和年龄匹配的男性血液流变学特性。结果发现，男性血液具有增加的粘度，红细胞聚集性和红细胞刚性。此外，发现雄性RBC具有更高的机械脆性。由于育龄妇女的老年红细胞几乎是男性的一半，年轻红细胞几乎是男性的两倍，我们研究了红细胞体内老化对其机械性能的影响。与年轻RBC相比，老年RBC显示出增加的机械脆性和聚集性，以及降低的变形性。红细胞的变形性降低和聚集性增加导致血液粘度增加，被称为心血管疾病的危险因素。由于男性拥有更多的旧红细胞与次优的机械性能比绝经前的妇女，谁由于每月失血有更多的年轻细胞和数量较低的旧红细胞比男性同行，我们的研究结果表明，男性的血液流变风险升高与红细胞的年龄分布。除了血细胞比容明显较高外，这可能是男性心血管疾病发病率和死亡率高于育龄女性的原因。
We hypothesized that due to monthly bloodloss, the mechanical properties of blood of premenopausal women are superior to men, and place them at less risk for cardiovascular diseases than men in any age group. Rheological properties of blood of premenopausal women and age-matched men were compared. It was found that male blood possesses an increased viscosity, RBC aggregability and RBC rigidity. Additionally, male RBCs were found to have higher mechanical fragility. Since women in reproductive age have almost half as many old RBCs and almost twice as many young RBCs as men, we investigated the effect of in vivo aging of RBCs on their mechanical properties. Old RBCs were shown to have an increased mechanical fragility and aggregability, and decreased deformability as compared to young RBCs. Decreased deformability and increased aggregability of RBCs cause an increase in blood viscosity and are known as risk factors of cardiovascular diseases. Since men possess a higher number of old RBCs with suboptimum mechanical properties than premenopausal women, who due to monthly bloodloss have a higher number of young cells and a lower number of old RBCs than their male counterparts, our results suggest that an elevated hemorheological risk for males is associated with the age distribution of RBCs. This, in addition to significantly higher hematocrit, may be the reason for the increased risk of morbidity and mortality from cardiovascular diseases of men as compared to women of reproductive age.