Effects of photodynamic therapy using talaporfin sodium (Laserphyrin ® ) on wound healing in an animal model
Effects of photodynamic therapy using talaporfin sodium (Laserphyrin ® ) on wound healing in an animal model
复制标题
使用他拉泊芬钠 (Laserphyrin ® ) 进行光动力疗法对动物模型伤口愈合的影响
DOI：
10.11343/amn.58.73
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发表时间：
2013
影响因子：
--
通讯作者：
T. Nagayasu
中科院分区：
文献类型：
--
作者：
G. Murakami;A. Nanashima;T. Nonaka;H. Isomoto;K. Takagi;J. Arai;G. Hatachi;Takafumi Abo;T. Nagayasu
背景：光动力疗法(PDT)是一种治疗局部晚期癌症的有效方法，有望作为术前新辅助化疗。这项研究的目的是阐明使用光敏剂他拉普芬钠(激光)的PDT对伤口愈合的不良影响。方法：PDT采用波长660 nm、频率10 Hz、总能量流畅度为60J/cm2的激光。在4周龄雄性BALB/c小鼠体内观察PDT后创面愈合的大体和组织学结果。结果：模型1分别于PDT后0、3、7d切开皮肤(n=3)，切开7d后各组创面愈合相似，组织学观察再生上皮和成纤维细胞数量无明显差异。在模型2中，在PDT之前或之后产生皮肤缺损，在第7天时，在PDT之前或之后有皮肤缺损组的皮肤缺损的大小比没有PDT的组大。然而，在第14天，所有组的大体伤口愈合都是完全的，到这一点，组之间没有显著差异。第14天皮肤缺损处的组织学结果显示，PDT组和未加PDT组在再生上皮和成纤维细胞数量方面没有显著差异。结论：PDT不影响创面愈合，可在手术治疗前安全应用。NAGASAKIENSIA学报58：73−77,2013
Background: Photodynamic therapy (PDT) is an effective laser treatment for locally advanced carcinoma and is promising as neoadjuvant chemotherapy before surgery. The aim of this study was to clarify the adverse effects of PDT using a photosensitizer, talaporfin sodium (Laserphyrin ® ), for wound healing. Methodology: For PDT, a laser light with a wavelength of 660 nm and a frequency of 10 Hz with a total energy fluency of 60 J/cm 2 was used. Macroscopic and histological findings of wound healing after PDT were examined in vivo (4-week-old male BALB/c mice). Results: In Model 1, in which skin was cut at 0, 3, 7 days after PDT (n=3, each), wounds were similarly healed 7 days after cutting in all groups, and regenerating epithelium and the number of fibroblasts on histological findings were not different. In Model 2, in which skin defects were created before or after PDT, the size of the defects was larger at day 7 in the groups with skin defects before or after PDT in comparison with groups with no PDT. However, macroscopic wound healing at day 14 was complete in all groups and there were no significant differences among the groups by this point. Histological findings of skin defects at day 14 showed no significant difference in terms of regenerat ing epithelium and number of fibroblasts in each group with or without PDT. Conclusions: PDT did not influence wound healing and can be safely applied before surgical therapy. ACTA MEDICA NAGASAKIENSIA 58: 73−77, 2013
影响因子：
6
作者：
Gao L;Li GS;Li JD;He J;Zhang Y;Zhou HF;Kong JL;Chen G
通讯作者：
Chen G
影响因子：
11.2
作者：
C. Gomer;A. Ferrario
通讯作者：
C. Gomer;A. Ferrario