Synthesis of Light-Induced Expandable Photoresponsive Polymeric Nanoparticles for Triggered Release.
Synthesis of Light-Induced Expandable Photoresponsive Polymeric Nanoparticles for Triggered Release.
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DOI：
10.1002/cplu.201300212
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发表时间：
2013-10
期刊：
影响因子：
3.4
通讯作者：
Zhen Wang;Peng Wang;Xinjing Tang
中科院分区：
文献类型：
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作者：
Zhen Wang;Peng Wang;Xinjing Tang
药物递送纳米载体在血液循环过程中的高稳定性对于有效的药物递送和低系统毒性是至关重要的，尽管当它们到达靶位点时，这些纳米载体的不稳定性是有效释放所必需的。为了开发高效的聚合物纳米载体，我们打算通过细乳液聚合来合成和表征一组交联的、光诱导的、可膨胀的聚合物纳米颗粒。这些合成的纳米粒子在水溶液中是稳定的，虽然光照射导致粒子uncaging和进一步的粒子膨胀高达315倍的体积。这导致包封的内容物在水溶液和三种细胞系（HeLa、RAW264.7和MCF-7）中的有效释放。选择性触发释放也成功地实现了空间分辨率在细胞单层。实现了姜黄素的包封和光调控释放。包封的姜黄素的进一步的细胞活力成功地实现了光活化。
High stability of drug-delivery nanocarriers during blood circulation is critical for effective drug delivery and low systematic toxicity, although destabilization of these nanocarriers is required for efficient release when they reach target sites. To develop efficient polymeric nanocarriers, we intended to synthesize and characterize a group of cross-linked, light-induced, expandable, polymeric nanoparticles through miniemulsion polymerization. These synthesized nanoparticles were stable in aqueous solutions, although light irradiation led to particle uncaging and further particle expansion up to 315-fold in volume. This resulted in the efficient release of the encapsulated contents in aqueous solutions and three cell lines (HeLa, RAW264.7, and MCF-7). Selective triggered release was also successfully achieved with spatial resolution in cell monolayers. In addition, curcumin encapsulation and photoregulation of its release were realized. Further cell viability of encapsulated curcumin was successfully achieved with light activation.