Encoding of social state information by neuronal activities in the macaque caudate nucleus
Encoding of social state information by neuronal activities in the macaque caudate nucleus
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DOI：
10.1080/17470919.2011.578465
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发表时间：
2012-01-01
影响因子：
2
通讯作者：
Nakahara, Hiroyuki
中科院分区：
文献类型：
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作者：
Santos, Gustavo S.;Nagasaka, Yasuo;Nakahara, Hiroyuki
社会性动物根据社会关系和瞬间的环境来调整自己的行为。支配-服从关系调节，但不完全决定，他们的竞争行为。例如，一只顺从的猴子是否决定去拿食物，不仅取决于是否有占支配地位的同伴，还取决于观察到的它们的行为。因此，行为表达需要对奖励结果和瞬时社会状态进行动态评估。这种评估背后的神经机制仍然难以捉摸。尾状核（CN）在代表奖励期望并将其转化为行动选择方面起着关键作用。为了研究它们的活动是否编码了社会状态信息，我们记录了猴子的CN神经元，同时它们与占主导地位的竞争对手进行竞争性食物抓取任务。我们发现了两组CN神经元：一组主要对奖励结果做出反应，而另一组主要跟踪猴子的社会状态。这些社会状态依赖的神经元表现出更大的活动时，猴子自由地取回食物，没有积极的挑战，从竞争对手和减少活动时，猴子是在一个顺从的状态，由于竞争对手的积极行为。这些结果表明，不同的神经元活动在CN编码的社会状态信息和奖励相关的信息，这可能有助于调整竞争行为在动态的社会背景。
Social animals adjust their behavior according to social relationships and momentary circumstances. Dominant-submissive relationships modulate, but do not completely determine, their competitive behaviors. For example, a submissive monkey's decision to retrieve food depends not only on the presence of dominant partners but also on their observed behavior. Thus, behavioral expression requires a dynamic evaluation of reward outcome and momentary social states. The neural mechanisms underlying this evaluation remain elusive. The caudate nucleus (CN) plays a pivotal role in representing reward expectation and translating it into action selection. To investigate whether their activities encode social state information, we recorded from CN neurons in monkeys while they performed a competitive food-grab task against a dominant competitor. We found two groups of CN neurons: one primarily responded to reward outcome, while the other primarily tracked the monkey's social state. These social state-dependent neurons showed greater activity when the monkeys freely retrieved food without active challenges from the competitor and reduced activity when the monkeys were in a submissive state due to the competitor's active behavior. These results indicate that different neuronal activities in the CN encode social state information and reward-related information, which may contribute to adjusting competitive behavior in dynamic social contexts.