Distinction between fibrinogen and fibrin degradation products in plasma.
Distinction between fibrinogen and fibrin degradation products in plasma.
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血浆中纤维蛋白原和纤维蛋白降解产物的区别。
DOI：
10.1016/0009-8981(75)90341-1
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
P. J. Gaffney
中科院分区：
文献类型：
--
作者：
P. J. Gaffney
十二烷基硫酸钠（SDS）中的聚丙烯酰胺（PA）凝胶电泳已被证明可以区分纯化的交联纤维蛋白和纤维蛋白原的纤溶酶诱导裂解物中的主要成分。交联纤维蛋白的D二聚体片段在SDS-PA凝胶上与纤维蛋白原片段X、Y、D g和E分离。免疫吸收后的纤溶酶诱导的血浆凝块，血浆纤维蛋白原，和两者的混合物的裂解物，纤维蛋白原和纤维蛋白的主要片段能够被区分的SDSPA凝胶电泳。患者血浆中D二聚体的存在表明肝素在治疗羊水栓塞相关出血中的有效性。
Polyacrylamide (PA) gel electrophoresis in sodium dodecyl sulphate (SDS) has been shown to distinguish between the major components in the plasmin induced lysates of purified crosslinked fibrin and fibrinogen. The D dimer fragment from crosslinked fibrin separated on SDS-PA gels from the fibrinogen fragments X, Y, Dgand E. Following immuno-absorption of plasmin induced lysates of plasma clots, plasma fibrinogen, and mixtures of both, the major fragments of fibrinogen and fibrin were capable of being discriminated by SDSPA gel electrophoresis. The presence of D dimer in patient plasma suggested the efficacy of heparin in the management of haemorrhage associated with amniotic fluid embolism.