Procalcitonin as a predictor of severe appendicitis in children
Procalcitonin as a predictor of severe appendicitis in children
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DOI：
10.1007/s10096-005-1360-4
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发表时间：
2005-07-01
影响因子：
4.5
通讯作者：
Androulakakis, E
中科院分区：
文献类型：
--
作者：
Kafetzis, DA;Velissariou, IM;Androulakakis, E
本研究的目的是评估降钙素原（PCT）在212例阑尾炎患儿中的诊断价值，并将其与标准诊断模式、C反应蛋白（CRP）水平、白细胞计数和腹部超声检查结果进行比较，并与阑尾的手术和组织学检查结果进行比较。PCT值> 0.5 ng/ml提示穿孔或坏疽，敏感性为73.4%，特异性为94.6%，CRP水平> 50 mg/l和白细胞计数> 10（4）/mm（3）是穿孔的有用诊断标志物，腹部超声诊断阑尾炎的敏感性为82.8%，特异性为91.2%。PCT测定是诊断急性坏死性阑尾炎或穿孔的有效方法，PCT> 0.5ng/ml者可能需要手术探查。
The aim of this study was to assess the diagnostic value of procalcitonin (PCT) in 212 children with appendicitis and compare it with that of the standard diagnostic modalities, C-reactive protein (CRP) level, leukocyte count, and abdominal ultrasound findings, in relation to the surgical and histological findings of the appendix. A PCT value of > 0.5 ng/ml was found to be indicative of perforation or gangrene with 73.4% sensitivity and 94.6% specificity, a CRP level of > 50 mg/l and a leukocyte count of > 10(4)/mm(3) were useful diagnostic markers for perforation, while abdominal ultrasonography had a sensitivity of 82.8% and a specificity of 91.2% for detecting appendicitis with imaging findings. PCT measurement seems to be a useful adjunctive tool for diagnosing acute necrotizing appendicitis or perforation, and surgical exploration will probably be required in patients with PCT values > 0.5 ng/ml.