Characterization of Mexican Americans with mild cognitive impairment and Alzheimer's disease.
Characterization of Mexican Americans with mild cognitive impairment and Alzheimer's disease.
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DOI：
10.3233/jad-2012-121420
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Hall J
中科院分区：
文献类型：
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作者：
O'Bryant SE;Johnson L;Balldin V;Edwards M;Barber R;Williams B;Devous M;Cushings B;Knebl J;Hall J
提供符合阿尔茨海默病（AD）和轻度认知障碍（MCI）标准的墨西哥裔美国人的特征。1069名年龄在40岁及以上的参与者，他们自认为是非西班牙裔白色（n=633）或墨西哥裔美国人（n=436）;使用基于社区的参与性研究（CBPR）方法招募。通过简易精神状态检查（MMSE）评估整体认知，通过临床痴呆评定量表（CDR）评估痴呆严重程度，通过老年抑郁量表30项版本评估抑郁。分析年龄、性别、文化程度、ApoEε4等位基因频率和糖尿病诊断。墨西哥裔美国人（正常对照、MCI和AD）更年轻，受教育程度更低，MMSE表现更差，支持更多抑郁症状，更容易被诊断为糖尿病，并且拥有ApoEε4等位基因的频率更低。年龄是墨西哥裔美国人中认知功能障碍（AD/MCI）的唯一显著危险因素（OR=1.06，95%CI = 1.03-1.09）。年龄（B=0.07，std=0.02，p<0.001）和ApoEε4存在（B=0.9，std=0.4，p=0.02）与疾病严重程度增加显著相关。鉴于墨西哥裔美国人人口的迅速增长和老龄化，在这个种族群体中，对认知老化，MCI和AD的研究是非常必要的。目前的研究结果对临床和研究环境都有重要意义，并指出了额外的研究需求。
To provide characterization of Mexican Americans who meet criteria for Alzheimer’s Disease (AD) and Mild Cognitive Impairment (MCI). 1069 participants ages 40 and above who self-identified as either non-Hispanic white (n=633) or Mexican American (n=436); were recruited using a community-based participatory research (CBPR) approach. Global cognition was assessed via the Mini Mental State Exam (MMSE), dementia severity by the Clinical Dementia Rating Scale (CDR) and depression via the Geriatric Depression Scale 30-item version. Age, gender, education, ApoEε4 allele frequency and diabetic diagnoses were also analyzed. Mexican Americans (normal controls, MCI and AD) were younger, less highly educated, performed more poorly on the MMSE, endorsed more symptoms of depression, were more likely to be diagnosed with diabetes, and possessed the ApoEε4 allele less frequently. Age was the only significant risk factor for cognitive dysfunction (AD/MCI) among Mexican Americans (OR=1.06, 95% CI = 1.03–1.09). Age (B=0.07, std=0.02, p<0.001) and ApoEε4 presence (B=0.9, std=0.4, p=0.02) were significantly related to increased disease severity. Given the rapidly growing and aging Mexican American population, there is a substantial need for research into cognitive aging, MCI and AD among this ethnic group. The current findings hold important implications for both clinic and research settings and point to additional research needs.