Characterization of diffraction-enhanced imaging contrast in breast cancer.

Characterization of diffraction-enhanced imaging contrast in breast cancer.
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乳腺癌衍射增强成像对比度的表征。

DOI:
10.1088/0031-9155/54/10/019
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发表时间:
2009
影响因子:
3.5
通讯作者:
Zhong,Z
Zhong,Z
中科院分区:
工程技术2区
文献类型:
--
作者:
Kao,T;Connor,D;Dilmanian,FA;Faulconer,L;Liu,T;Parham,C;Pisano,ED;Zhong,Z

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衍射增强成像(DEI)是一种新的X射线成像模式,已被证明可以增强正常和癌性乳腺组织之间的对比度。在这项研究中,计算机断层扫描(DEI-CT)模式中的衍射增强成像被用来定量表征与浸润性人类乳腺癌相关的组织结构的折射对比度。采用高灵敏度的Si(333)反射,观察乳腺癌的个体特征,包括肿块、钙化和毛刺。与使用相同探测器、X射线能量和剂量对相同标本进行的常规CT相比,DEI-CT对肿块、钙化和毛刺的CT值分别高出14、5和7倍,信噪比(SNR)分别高出10、9和6倍。此外,DEI-CT在低十倍的剂量下产生比传统CT更好的SNR。根据最近开发的使用X射线管作为其源的紧凑型DEI原型,在临床前DEI原型存在的临床相关X射线能量下获得的这些结果表明,使用DEI-CT进行乳房X射线摄影的临床实施具有提供乳腺癌的高对比度、高分辨率图像的潜力(帕勒姆2006 PhD Dissertation University of北卡罗来纳州at查佩尔山)。
Diffraction-enhanced imaging (DEI) is a new x-ray imaging modality that has been shown to enhance contrast between normal and cancerous breast tissues. In this study, diffraction-enhanced imaging in computed tomography (DEI-CT) mode was used to quantitatively characterize the refraction contrasts of the organized structures associated with invasive human breast cancer. Using a high-sensitivity Si (3 3 3) reflection, the individual features of breast cancer, including masses, calcifications and spiculations, were observed. DEI-CT yields 14, 5 and 7 times higher CT numbers and 10, 9 and 6 times higher signal-to-noise ratios (SNR) for masses, calcifications and spiculations, respectively, as compared to conventional CT of the same specimen performed using the same detector, x-ray energy and dose. Furthermore, DEI-CT at ten times lower dose yields better SNR than conventional CT. In light of the recent development of a compact DEI prototype using an x-ray tube as its source, these results, acquired at a clinically relevant x-ray energy for which a pre-clinical DEI prototype currently exists, suggest the potential of clinical implementation of mammography with DEI-CT to provide high-contrast, high-resolution images of breast cancer (Parham 2006 PhD Dissertation University of North Carolina at Chapel Hill).
玻璃体切除术治疗糖尿病牵引性黄斑视网膜脱离的结果和预后因素。
DOI: 10.1001/archopht.1987.01060040067035
发表时间: 1987
影响因子: --
作者:
John T. Thompson;S. D. Bustros;R. Michels;T. Rice
通讯作者: T. Rice
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DOI: --
发表时间: 1989
期刊: A M A Archives of Ophthalmology
影响因子: --
作者:
George A. Williams;Gary W. Abrams;W. Mieler
通讯作者: W. Mieler
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DOI: --
发表时间: 1981
期刊: Retina
影响因子: --
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R. Michels
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DOI: --
发表时间: 1987
期刊: American journal of ophthalmology-glaucoma
影响因子: --
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Gary W. Abrams;George A. Williams
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DOI: 10.1016/0002-9394(87)90173-5
发表时间: 1987-12-15
影响因子: 4.2
作者:
LEWIS, H;ABRAMS, GW;WILLIAMS, GA
通讯作者: WILLIAMS, GA