Mobile contingency locus controlling Escherichia coli K1 polysialic acid capsule acetylation.
Mobile contingency locus controlling Escherichia coli K1 polysialic acid capsule acetylation.
复制标题
控制大肠杆菌K1聚唾液酸胶囊乙酰化的移动应急位点。
DOI：
10.1111/j.1365-2958.2006.05158.x
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Steenbergen,SusanM
中科院分区：
文献类型：
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作者：
Vimr,EricR;Steenbergen,SusanM
大肠杆菌1是附着性侵袭性兼性病原体储存库的一部分，可导致多种人类和动物疾病，包括败血症、脑膜炎、尿路感染和炎症性肠综合征。在这些疾病中一个突出的毒力因子是多唾液酸荚膜多糖（K1抗原），它是由插入在phevat附近的kps/ neuac增生结构域编码的。SomeE。coliK1菌株经历了形式（相）变化，包括在聚唾液酸链的单个唾液酸残基的7或9碳位上的O -乙酰酯的损失或增加。乙酰化是由neuo编码的受体修饰乙酰辅酶A依赖性O乙酰转移酶催化的，这是一个相位可变位点，位于K1特异性噬菌体CUS - 3的整合酶基因附近，插入到argwat 53.1个图谱单元中。作为第一个。因此，进一步的研究将有助于更好地了解侵袭性K1的病理类型。与肠道外致病性引起的人类感染相关的发病率和经济成本的最低估计。K1等大肠杆菌表明，仅在美国，每年至少有650万例病例，随之而来的医疗费用超过25亿美元。
Escherichia coliK1 is part of a reservoir of adherent, invasive facultative pathogens responsible for a wide range of human and animal disease including sepsis, meningitis, urinary tract infection and inflammatory bowel syndrome. A prominent virulence factor in these diseases is the polysialic acid capsular polysaccharide (K1 antigen), which is encoded by thekps/neuaccretion domain inserted nearpheVat 67 map units. SomeE. coliK1 strains undergo form (phase) variation involving loss or gain of O‐acetyl esters at carbon positions 7 or 9 of the individual sialic acid residues of the polysialic acid chains. Acetylation is catalysed by the receptor‐modifying acetyl coenzyme‐A‐dependent O‐acetyltransferase encoded byneuO, a phase variable locus mapping near the integrase gene of the K1‐specific prophage, CUS‐3, which is inserted inargWat 53.1 map units. As the firstE. colicontingency locus shown to operate by a translational switch, further investigation ofneuOshould provide a better understanding of the invasive K1 pathotype. Minimal estimates of morbidity and economic costs associated with human infections caused by extraintestinal pathogenicE. colistrains such as K1 indicate at least 6.5 million cases with attendant medical costs exceeding $2.5 billion annually in the United States alone.