New biologically active rubiginones from Streptomyces sp.
New biologically active rubiginones from Streptomyces sp.
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DOI：
10.7164/antibiotics.53.329
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发表时间：
2000-04-01
影响因子：
3.3
通讯作者：
Beil, W
中科院分区：
文献类型：
--
作者：
Puder, C;Zeeck, A;Beil, W
从Streptomyces sp. （Go N1/5）培养物中分离到4个新的聚酮，分别命名为rubiginone D-2(2)、4- o -乙酰-rubiginone D-2(3)、rubiginone H(6)和rubiginone I(7)。通过详细的光谱分析确定了它们的结构。通过手性酸衍生化（Helmchen法）确定了3的绝对构型。鲁比金酮抑制一些革兰氏阳性细菌的生长，并对不同的肿瘤细胞系具有细胞抑制活性。
Four new polyketides, named rubiginone D-2 (2), 4-O-acetyl-rubiginone D-2 (3), rubiginone H (6) and rubiginone I (7) were isolated from the cultures of Streptomyces sp. (strain Go N1/5). Their structures were established by a detailed spectroscopic analysis. The absolute configuration of 3 was determined by derivatization with chiral acids (Helmchen's method). The rubiginones inhibit the growth of some Gram-positive bacteria and are cytostatically active against different tumor cell lines.