Exposure to mild blast forces induces neuropathological effects, neurophysiological deficits and biochemical changes.
Exposure to mild blast forces induces neuropathological effects, neurophysiological deficits and biochemical changes.
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DOI：
10.1186/s13041-018-0408-1
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发表时间：
2018-11-09
期刊：
影响因子：
3.6
通讯作者：
Bibb JA
中科院分区：
文献类型：
--
作者：
Hernandez A;Tan C;Plattner F;Logsdon AF;Pozo K;Yousuf MA;Singh T;Turner RC;Lucke-Wold BP;Huber JD;Rosen CL;Bibb JA
直接或间接暴露于爆炸可引起不同严重程度的创伤性脑损伤（TBI）。冲击波暴露的原发性TBI通常以内部损伤为特征，如血管损伤、神经元损伤和挫伤，而无外部损伤。目前的爆炸诱导TBI（bTBI）的动物模型有助于了解中度至重度爆炸力的有害影响。然而，轻微爆炸力对神经系统的影响仍不明确。在这里，我们研究了轻微的冲击力所造成的影响，结合神经病理学，组织学，生化和神经生理学分析。为此，我们采用了啮齿动物冲击TBI模型，冲击力低于导致宏观神经病理学变化的水平。我们发现，轻微的冲击力诱导大脑皮层，纹状体和海马神经炎症。此外，轻度冲击波可引起微血管损伤和轴索损伤。此外，轻度冲击波引起海马短时程可塑性和突触兴奋性的缺陷，但没有损害长时程增强。最后，轻度冲击波暴露诱导蛋白水解裂解血影蛋白和细胞周期蛋白依赖性激酶5激活剂，p35在海马。总之，这些研究结果表明，轻微的冲击力会导致严重影响神经元功能的异常神经变化。这些结果是一致的想法，轻度冲击力可能会引起亚临床病理生理变化，可能有助于神经和精神疾病。
Direct or indirect exposure to an explosion can induce traumatic brain injury (TBI) of various severity levels. Primary TBI from blast exposure is commonly characterized by internal injuries, such as vascular damage, neuronal injury, and contusion, without external injuries. Current animal models of blast-induced TBI (bTBI) have helped to understand the deleterious effects of moderate to severe blast forces. However, the neurological effects of mild blast forces remain poorly characterized. Here, we investigated the effects caused by mild blast forces combining neuropathological, histological, biochemical and neurophysiological analysis. For this purpose, we employed a rodent blast TBI model with blast forces below the level that causes macroscopic neuropathological changes. We found that mild blast forces induced neuroinflammation in cerebral cortex, striatum and hippocampus. Moreover, mild blast triggered microvascular damage and axonal injury. Furthermore, mild blast caused deficits in hippocampal short-term plasticity and synaptic excitability, but no impairments in long-term potentiation. Finally, mild blast exposure induced proteolytic cleavage of spectrin and the cyclin-dependent kinase 5 activator, p35 in hippocampus. Together, these findings show that mild blast forces can cause aberrant neurological changes that critically impact neuronal functions. These results are consistent with the idea that mild blast forces may induce subclinical pathophysiological changes that may contribute to neurological and psychiatric disorders.
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影响因子：
17.1
作者：
Goldstein LE;Fisher AM;Tagge CA;Zhang XL;Velisek L;Sullivan JA;Upreti C;Kracht JM;Ericsson M;Wojnarowicz MW;Goletiani CJ;Maglakelidze GM;Casey N;Moncaster JA;Minaeva O;Moir RD;Nowinski CJ;Stern RA;Cantu RC;Geiling J;Blusztajn JK;Wolozin BL;Ikezu T;Stein TD;Budson AE;Kowall NW;Chargin D;Sharon A;Saman S;Hall GF;Moss WC;Cleveland RO;Tanzi RE;Stanton PK;McKee AC
通讯作者：
McKee AC
影响因子：
6.1
作者：
Park, Eugene;Eisen, Rebecca;Baker, Andrew J.
通讯作者：
Baker, Andrew J.
影响因子：
12.7
作者：
Greer, John E.;Hanell, Anders;Povlishock, John T.
通讯作者：
Povlishock, John T.
影响因子：
5.3
作者：
Albensi, BC;Sullivan, PG;Mattson, MP
通讯作者：
Mattson, MP
影响因子：
7.4
作者：
Ansari, Mubeen A.;Roberts, Kelly N.;Scheff, Stephen W.
通讯作者：
Scheff, Stephen W.