THE AMYGDALOSTRIATAL PROJECTION IN THE RAT - AN ANATOMICAL STUDY BY ANTEROGRADE AND RETROGRADE TRACING METHODS
THE AMYGDALOSTRIATAL PROJECTION IN THE RAT - AN ANATOMICAL STUDY BY ANTEROGRADE AND RETROGRADE TRACING METHODS
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DOI：
10.1016/0306-4522(82)90067-7
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发表时间：
1982-01-01
期刊：
影响因子：
3.3
通讯作者：
NAUTA, WJH
中科院分区：
文献类型：
--
作者：
KELLEY, AE;DOMESICK, VB;NAUTA, WJH
氚标记的亮氨酸和脯氨酸注入杏仁复合体标记的大量amygdalostriatal纤维系统，这是分布到纹状体的所有部分，除了前背外侧纹状体部门。连接通过纵行联合束和终纹建立，包括适度（10-15%）的对称分布的对侧成分，由前连合传递。放射自显影的结果和随后的观察逆行细胞标记（辣根过氧化物酶）材料表明，杏仁体纹状体的投影主要来自基底核外侧杏仁核，在小得多的体积从基底核内侧，最低限度地从杏仁核外侧;没有其他贡献杏仁核细胞群可以确定。与以前的报告的比较表明，amygdalostriatal投影广泛重叠的腹侧被盖区，中脑中缝核和前额皮质的纹状体的预测。像杏仁核纹状体投射，这些纹状体传入大部分或完全避免前背外侧纹状体象限，这似乎是最稀疏的传入神经支配的纹状体区域起源于边缘系统的电路内的结构。在额外的放射自显影材料的结果确定这相对非limibic纹状体象限的主要区域分布的皮质纹状体投射从感觉运动皮层。
Tritiated leucine and proline injected into the amygdaloid complex labeled a voluminous amygdalostriatal fiber system, which is distributed to all parts of the striatum except an antero-dorsolateral striatal sector. The connection is established by way of the longidutinal association bundle and the stria terminalis, and includes a modest (10-15%), symmetrically distributed contralateral component conveyed by the anterior commissure. Both autoradiographic findings and subsequent observations in retrograde cell-labeling (horseradish peroxidase) material indicate that the amygdalostriatal projection originates mainly from the nucleus basalis lateralis amygdalae, in much lesser volume from the nucleus basalis medialis, and minimally from the nucleus lateralis amygdalae; no other contributing amygdaloid cell group could be identified. A comparison with earlier reports indicates that the amygdalostriatal projection widely overlaps the striatal projections from the ventral tegmental area, the mesencephalic raphe nuclei and the prefrontal cortex. Like the amygdalostriatal projection, these striatal afferents largely or entirely avoid the antero-dorsolateral striatal quadrant, which appears to be the striatal region most sparsely innervated by afferents originating from structures within the circuitry of the limbic system. Findings in additional autoradiographic material identify this relatively non-limibic striatal quadrant as the main region of distribution of the corticostriatal projection from the sensorimotor cortex.