Forward and Reverse Signaling Mediated by Transmembrane Tumor Necrosis Factor-Alpha and TNF Receptor 2: Potential Roles in an Immunosuppressive Tumor Microenvironment.
Forward and Reverse Signaling Mediated by Transmembrane Tumor Necrosis Factor-Alpha and TNF Receptor 2: Potential Roles in an Immunosuppressive Tumor Microenvironment.
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跨膜肿瘤坏死因子-α 和 TNF 受体 2 介导的正向和反向信号传导：在免疫抑制肿瘤微环境中的潜在作用
DOI：
10.3389/fimmu.2017.01675
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发表时间：
2017
影响因子：
7.3
通讯作者：
Li H
中科院分区：
文献类型：
--
作者：
Qu Y;Zhao G;Li H
肿瘤坏死因子-α是一种多效性炎性细胞因子，主要由活化的巨噬细胞、淋巴细胞等多种细胞产生。目前已鉴定出两种不同形式的肿瘤坏死因子-α：可溶性肿瘤坏死因子-α(sTNF-α)和跨膜型肿瘤坏死因子-α(mtnf-α)。肿瘤坏死因子-α是肿瘤坏死因子-α的前体，可被肿瘤坏死因子-α转换酶切割，释放为肿瘤坏死因子-α。肿瘤坏死因子-α主要与肿瘤坏死因子受体1结合，在炎症免疫反应中发挥重要作用，而肿瘤坏死因子-α主要与肿瘤坏死因子受体2相互作用，介导促进细胞增殖和存活等生物学效应。据报道，mtnf-α和tnfr2之间的相互作用在mtnf-α和tnfr2表达细胞中都能诱导双向(正向和反向)信号传导。越来越多的证据表明，mtnf-α和TNFR2介导的正向和反向信号可能在肿瘤微环境中发挥重要作用。在这篇综述中，将讨论mtnf-α和tnfr2之间的串扰在肿瘤微环境中的作用。
Tumor necrosis factor-alpha (TNF-α) is a pleiotropic inflammatory cytokine produced mainly by activated macrophages, lymphocytes and other cell types. Two distinct forms of TNF-α have been identified: soluble TNF-α (sTNF-α) and transmembrane TNF-α (mTNF-α). mTNF-α, which is the precursor of sTNF-α, can be cleaved by the TNF-α converting enzyme (TACE) and is released as sTNF-α. sTNF-α binds primarily to TNF receptor 1 (TNFR1) and plays an important role in the inflammatory immune response, whereas mTNF-α interacts primarily with TNF receptor 2 (TNFR2) and mediates the promotion of cellular proliferation and survival and other biological effects. It has been reported that the interaction between mTNF-α and TNFR2 induces bi-directional (forward and reverse) signaling in both mTNF-α- and TNFR2-expressing cells. Increasing evidence shows that the forward and reverse signaling mediated by mTNF-α and TNFR2 might play a significant role in the tumor microenvironment. In this review, the role of the crosstalk between mTNF-α and TNFR2 in the tumor microenvironment will be discussed.
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影响因子：
5.5
作者：
Kirchner, S;Boldt, S;Eissner, G
通讯作者：
Eissner, G
影响因子：
11.2
作者：
Ardestani S;Li B;Deskins DL;Wu H;Massion PP;Young PP
通讯作者：
Young PP
DOI：
10.1093/rheumatology/keq031
发表时间：
2010-07
期刊：
Rheumatology (Oxford, England)
影响因子：
--
作者：
Horiuchi T;Mitoma H;Harashima S;Tsukamoto H;Shimoda T
通讯作者：
Shimoda T
DOI：
10.1186/ar558
发表时间：
2002
期刊：
Arthritis research
影响因子：
--
作者：
Burger D;Dayer JM
通讯作者：
Dayer JM
影响因子：
11.2
作者：
Bunt, Stephanie K.;Yang, Linglin;Ostrand-Rosenberg, Suzanne
通讯作者：
Ostrand-Rosenberg, Suzanne