Fever-induced Brugada pattern: how common is it and what does it mean?
Fever-induced Brugada pattern: how common is it and what does it mean?
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DOI：
10.1016/j.hrthm.2013.07.030
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发表时间：
2013-09
期刊：
影响因子：
5.5
通讯作者：
Viskin, Sami
中科院分区：
文献类型：
--
作者：
Adler, Arnon;Topaz, Guy;Heller, Karin;Zeltser, David;Ohayon, Tami;Rozovski, Uri;Halkin, Amir;Rosso, Raphael;Ben-Shachar, Shay;Antzelevitch, Charles;Viskin, Sami
众所周知，发热会暴露出心电图上的Brugada模式，并在Brugada综合征患者中引发室性心律失常。对发热诱导的Brugada模式的选定病例的遗传学研究已经确定了致病突变。因此，“发热诱导的Brugada”是公认的临床实体。然而，它的流行程度还没有得到系统的评估。这项研究的目的是评估Brugada模式在连续发热患者中的患病率。对急诊科入院的发热患者的心电图进行了Brugada模式的评估，并与连续非发热患者的心电图进行了比较。对402例发热患者和909例非发热患者的心电图进行了检测。I型Brugada模式在发热组的发生率是发热组的20倍(分别为2%和0.1%，P=0.0001)。所有发热诱导的I型Brugada类型的患者都没有症状，并在30个月的随访中保持不变。I型Brugada模式在发热患者中明显更常见，这表明无症状Brugada综合征比先前估计的更普遍。
Fever is known to unmask the Brugada pattern on the electrocardiogram (ECG) and trigger ventricular arrhythmias in patients with Brugada syndrome. Genetic studies in selected cases with fever-induced Brugada pattern have identified disease-causing mutations. Thus, “fever-induced Brugada” is a recognized clinical entity. However, its prevalence has not been systematically evaluated. The purpose of this study was to assess the prevalence of Brugada pattern in consecutive patients with fever. ECGs of patients with fever admitted to the emergency department were evaluated for the presence of Brugada pattern and compared with ECGs of consecutive nonfebrile patients. ECGs of 402 patients with fever and 909 without were evaluated. Type I Brugada pattern was 20 times more common in the febrile group than in the afebrile group (2% vs 0.1%, respectively, P = .0001). All patients with fever-induced type I Brugada pattern were asymptomatic and remained so during 30 months of follow-up. Type I Brugada pattern is definitively more common among patients with fever, suggesting that asymptomatic Brugada syndrome is more prevalent than previously estimated.
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DOI：
10.1046/j.1540-8167.2001.00061.x
发表时间：
2001-01-01
影响因子：
2.7
作者：
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通讯作者：
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DOI：
10.1046/j.1540-8167.2002.00816.x
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影响因子：
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作者：
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影响因子：
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