Adulthood residential ultraviolet radiation, sun sensitivity, dietary vitamin D, and risk of lymphoid malignancies in the California Teachers Study
Adulthood residential ultraviolet radiation, sun sensitivity, dietary vitamin D, and risk of lymphoid malignancies in the California Teachers Study
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DOI：
10.1182/blood-2011-02-336065
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发表时间：
2011-08-11
期刊：
影响因子：
20.3
通讯作者：
Horn-Ross, Pamela L.
中科院分区：
文献类型：
--
作者：
Chang, Ellen T.;Canchola, Alison J.;Horn-Ross, Pamela L.
为了澄清先前关于紫外线辐射 (UVR) 暴露与淋巴恶性肿瘤风险之间存在负相关的不一致的研究结果，我们在加州教师研究队列中研究了前瞻性确定的居住环境紫外线辐射与非霍奇金淋巴瘤 (NHL)、多发性骨髓瘤 (MM) 和经典霍奇金淋巴瘤风险之间的关联。 1995-1996 年和 2007 年间，在 121 216 名符合条件的女性中，629 名被诊断为 NHL，119 名被诊断为 MM，38 名被诊断为霍奇金淋巴瘤。Cox 比例风险回归用于估计发病率比 (RR) 和 95% 置信区间 (CI)。 20 公里半径内的住宅 UVR 水平与整体 NHL 风险降低相关（最低 UVR 最高与最低全州四分位数的 RR [>= 5100 vs < 4915 W-h/m(2)]，0.58；95% CI，0.42-0.80），尤其是弥漫性大 B 细胞淋巴瘤（RR，0.36；95% CI， 0.17-0.78）和慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（RR，0.46；95% CI，0.21-1.01）和 MM（最大 UVR RR，0.57；95% CI，0.36-0.90）。这些关联不会因皮肤对阳光的敏感性、种族/民族、体重指数或社区社会经济地位而改变。膳食维生素 D 也与淋巴恶性肿瘤的风险无关。这些结果支持常规住宅紫外线照射通过可能独立于维生素 D 的机制对淋巴瘤发生具有保护作用。 (Blood. 2011;118(6):1591-1599)
To lend clarity to inconsistent prior findings of an inverse association between ultraviolet radiation (UVR) exposure and risk of lymphoid malignancies, we examined the association of prospectively ascertained residential ambient UVR exposure with risk of non-Hodgkin lymphomas (NHLs), multiple myeloma (MM), and classical Hodgkin lymphoma in the California Teachers Study cohort. Among 121 216 eligible women, 629 were diagnosed with NHL, 119 with MM, and 38 with Hodgkin lymphoma between 1995-1996 and 2007. Cox proportional hazards regression was used to estimate incidence rate ratios (RRs) with 95% confidence intervals (CIs). Residential UVR levels within a 20-km radius were associated with reduced risk of overall NHL (RR for highest vs lowest statewide quartile of minimum UVR [>= 5100 vs < 4915 W-h/m(2)], 0.58; 95% CI, 0.42-0.80), especially diffuse large B-cell lymphoma (RR, 0.36; 95% CI, 0.17-0.78) and chronic lymphocytic leukemia/small lymphocytic lymphoma (RR, 0.46; 95% CI, 0.21-1.01), and MM (RR for maximum UVR, 0.57; 95% CI, 0.36-0.90). These associations were not modified by skin sensitivity to sunlight, race/ethnicity, body mass index, or neighborhood socioeconomic status. Dietary vitamin D also was not associated with risk of lymphoid malignancies. These results support a protective effect of routine residential UVR exposure against lymphomagenesis through mechanisms possibly independent of vitamin D. (Blood. 2011;118(6):1591-1599)