PULMONARY VASCULAR-RESISTANCE IN THE FLUOROCARBON-FILLED LUNG
PULMONARY VASCULAR-RESISTANCE IN THE FLUOROCARBON-FILLED LUNG
复制标题
DOI：
10.1152/jappl.1986.60.1.154
复制
发表时间：
1986-01-01
影响因子：
3.3
通讯作者：
SHAFFER, TH
中科院分区：
文献类型：
--
作者：
LOWE, CA;SHAFFER, TH
肺血管阻力进行了研究，在氟碳填充肺在原位分离肺准备。将肺以恒定流量（100 ml. min-1. kg-1）。左心房压力保持恒定在零压力。测量肺动脉压能够计算肺血管阻力。肺血流的区域变化通过微球技术测定。在0-30 mmHg范围内的准静态放气过程中，一定体积的氟碳化合物的依赖性肺泡压力始终大于气体的依赖性肺泡压力，氟碳化合物填充肺的每个压力-体积曲线向充气肺的曲线的右侧移动。反过来，肺血管阻力被发现线性增加的肺泡压力增加的函数，独立的介质在肺。因此，对于给定的体积，与充气肺相比，氟碳填充肺的肺血管阻力始终更大。这种肺血管阻力的增加伴随着肺血流的重新分布，其中与充气肺相比，在充满氟碳化合物的肺中，流向依赖区域的血流减少。相反，与气体相比，当填充氟碳化合物时，肺的依赖性较低的区域接收相对更大百分比的血流。这些结果表明，肺血管阻力增加液体通气，主要是由于机械相互作用的肺泡血管界面。
Pulmonary vascular resistance was investigated in the fluorocarbon-filled lung in an in situ isolated lung preparation. Lungs were perfused at constant flow (100 ml .cntdot. min-1 .cntdot. kg-1) with whole blood from a donor cat. Left atrial pressure was held constant at zero pressure. Measurements of pulmonary arterial pressure enabled calculation of pulmonary vascular resistance. Regional changes in pulmonary blood flow were determined by the microsphere technique. During quasistatic deflation over a range of 0-30 mmHg, dependent alveolar pressure was consistently greater for a volume of fluorocarbon than for gas, with each pressure-volume curve for the fluorocarbon-filled lung shifted to the right of the curve for the gas-filled lung. In turn, pulmonary vascular resistance was found to increase linearly as a function of increasing alveolar pressure, independent of the medium in the lung. Thus, for a given volume, pulmonary vascular resistance was consistently greater in the fluorocarbon-filled lung compared with the gas-filled lung. This increase in pulmonary vascular resistance was accompanied by a redistribution of pulmonary blood flow in which blood flow to the dependent region was decreased in the fluorocarbon-filled lung compared with the gas-filled lung. Conversely, the less-dependent regions of the lung received a relatively greater percentage of blood flow when filled with fluorocarbon compared with gas. These findings suggest that pulmonary vascular resistance is increased during liquid ventilation, largely as the result of mechanical interaction at the alveolar-vascular interface.