Synthesis of some thiazolyl-pyrazoline derivatives and preliminary investigation of their hypotensive activity
Synthesis of some thiazolyl-pyrazoline derivatives and preliminary investigation of their hypotensive activity
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DOI：
10.1016/s0223-5234(00)00152-5
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发表时间：
2000-06-01
影响因子：
6.7
通讯作者：
Erol, K
中科院分区：
文献类型：
--
作者：
Turan-Zitouni, G;Chevallet, P;Erol, K
以1-硫代氨基甲酰基-3，5-二芳基-2-吡唑啉为原料，与苯乙酰溴在乙醇中反应，合成了一些1-(4-arylthiazol-2-yl)-3，5-diaryl-2-pyrazoline衍生物。化合物的结构经红外光谱、核磁共振氢谱、质谱图和元素分析确证。采用尾套法对13个化合物的降压活性进行了评价。所有被研究的化合物都显示出明显的降压活性。以可乐定为参照物进行药理评价。(C)2000年版《爱思唯尔科学与医学》。
Some 1-(4-arylthiazol-2-yl)-3,5-diaryl-2-pyrazoline derivatives were synthesized by reacting 1-thiocarbamoyl-3,5-diaryl-2-pyrazoline derivatives with phenacetylbromide in ethanol. The structural elucidation of the compounds were performed by IR, H-1-NMR and Mass spectral data and elemental analyses. The hypotensive activities of 13 compounds were evaluated by using the tail-cuff method. All examined compounds showed appreciable hypotensive activities. Clonidine was used as reference substance in the pharmacological evaluation. (C) 2000 Editions scientifiques et medicales Elsevier SAS.