KDM4A as a prognostic marker of oral squamous cell carcinoma: Evidence from tissue microarray studies in a multicenter cohort.
KDM4A as a prognostic marker of oral squamous cell carcinoma: Evidence from tissue microarray studies in a multicenter cohort.
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KDM4A 作为口腔鳞状细胞癌的预后标志物：多中心队列组织微阵列研究的证据
DOI：
10.18632/oncotarget.18302
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发表时间：
2017-10-06
期刊：
影响因子：
--
通讯作者：
Chen Q
中科院分区：
文献类型：
--
作者：
Jin X;Xu H;Wu X;Li T;Li J;Zhou Y;Dan H;Jiang L;Zeng X;Ji P;Chen Q
已有研究发现组蛋白去甲基化酶KDM4A是侵袭性鳞状细胞癌生长和转移的关键表观遗传启动因子。本研究的目的是利用多中心组织微阵列检测KDM4A作为口腔鳞状细胞癌的独立预后标志物。KDM4A的表达与淋巴结转移和TNM分期有显著相关性。KDM4A过表达与较差的总生存率相关，并且被发现是全因死亡率的具有统计学意义的独立预测因子。这些发现得到了外部TCGA HNSCC数据的验证。KDM4A表达的增加提高了标准临床病理特征预测癌症特异性生存的区分准确性（模型4，曲线下面积= 0.740,95%可信区间= 0.685 ~ 0.795，模型3，AUC = 0.695, 95% CI = 0.637 ~ 0.753）。利用313例OSCC样本的组织微阵列，通过免疫组织化学检测KDM4A的表达。采用Kruskal-Wallis检验和卡方检验探讨KDM4A表达与临床病理因素的相关性。采用Kaplan-Meier和多变量logistic回归模型进行总生存分析，并结合已知的OSCC危险因素评估KDM4A的预测能力。使用受试者工作特征曲线来评估这些模型的区分准确性。此外，对癌症基因组图谱数据库中报道的头颈部鳞状细胞癌患者的无病生存期进行了分析。KDM4A表达是OSCC患者生存时间的独立预测因子，可能是术后治疗选择的有价值的考虑因素。
Previous studies have identified histone demethylase KDM4A to be a key epigenetic priming factor for the invasive squamous cell carcinoma growth and metastasis. The purpose of this study was to examine KDM4A as an independent prognostic marker in oral squamous cell carcinoma, using multicenter tissue microarrays. The expression of KDM4A was significantly correlated with lymph node metastasis and TNM stage. KDM4A overexpression was associated with poor overall survival, and it was found to be a statistically significant independent predictor of all-cause mortality. These findings are validated by external TCGA HNSCC data. Addition of KDM4A expression improved the discriminatory accuracy of standard clinicopathologic features for prediction of cancer-specific survival (Model 4, area under the curve = 0.740, 95% confidence interval = 0.685 to 0.795, and Model 3, AUC = 0.695, 95% CI = 0.637 to 0.753, respectively). KDM4A expression was measured by immunohistochemistry, using tissue microarrays of OSCC samples collected from 313 patients. Kruskal-Wallis and chi-square tests were applied to investigate the correlation between KDM4A expression and clinicopathological factors. Overall survival analysis was performed using the Kaplan-Meier and multivariable logistic regression models, and the predictive ability of KDM4A in combination with known OSCC risk factors was evaluated. Receiver operating characteristic curves were used to assess discriminatory accuracy of these models. Additionally, disease-free survival was analyzed in patients with head and neck SCC reported on The Cancer Genome Atlas database. KDM4A expression is an independent predictor for the survival time of patients with OSCC and may be a valuable consideration to postoperative treatment options.
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影响因子：
24.5
作者：
Li J;Chen Z;Tian L;Zhou C;He MY;Gao Y;Wang S;Zhou F;Shi S;Feng X;Sun N;Liu Z;Skogerboe G;Dong J;Yao R;Zhao Y;Sun J;Zhang B;Yu Y;Shi X;Luo M;Shao K;Li N;Qiu B;Tan F;Chen R;He J
通讯作者：
He J
影响因子：
3.7
作者：
Wu, Cheng-Hsien;Wu, Tzu-Ying;Kao, Shou-Yen
通讯作者：
Kao, Shou-Yen
蛋白酶体激活剂 PA28γ 与口腔鳞状细胞癌结果之间的关联：来自队列研究和功能分析的证据。
影响因子：
11.1
作者：
Li J;Feng X;Sun C;Zeng X;Xie L;Xu H;Li T;Wang R;Xu X;Zhou X;Zhou M;Zhou Y;Dan H;Wang Z;Ji N;Deng P;Liao G;Geng N;Wang Y;Zhang D;Lin Y;Ye L;Liang X;Li L;Luo G;Jiang L;Wang Z;Chen Q
通讯作者：
Chen Q
影响因子：
2.3
作者：
Adsay, N. Volkan;Bagci, Pelin;Roa, Juan Carlos
通讯作者：
Roa, Juan Carlos
影响因子：
4
作者：
Kim, Tae-Dong;Shin, Sook;Janknecht, Ralf
通讯作者：
Janknecht, Ralf