Apolipoprotein E genotype in Korean schizophrenic patients.
Apolipoprotein E genotype in Korean schizophrenic patients.
复制标题
韩国精神分裂症患者的载脂蛋白 E 基因型。
DOI：
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发表时间：
2001
影响因子：
4.5
通讯作者：
D. Park
中科院分区：
文献类型：
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作者：
Mi;Ae Ja Park;Bum Yoo Nam;Kyung Joon Min;B. Kee;D. Park
The apolipoprotein E (APOE) epsilon4 allele is a known risk factor for the development of Alzheimer's disease, however, an association of the APOE genotype with schizophrenia is controversial.我们调查了 60 名韩国精神分裂症患者和 60 名健康对照者的关联性。 APOE 基因型通过基于反向杂交的线性探针测定法进行鉴定。精神分裂症患者和对照组之间APOE基因型分布存在显着差异。精神分裂症患者的 APOE epsilon2 和 epsilon3 等位基因频率与对照组显着不同。我们的结果表明 APOE 等位基因似乎在精神分裂症的发病机制中起作用。
The apolipoprotein E (APOE) epsilon4 allele is a known risk factor for the development of Alzheimer's disease, however, an association of the APOE genotype with schizophrenia is controversial. We investigated the association in 60 Korean schizophrenic patients and 60 healthy controls. APOE genotypes were identified by reverse hybridization-based line probe assay. There were significant differences in the distribution of APOE genotypes between schizophrenic patients and controls. APOE epsilon2 and epsilon3 allele frequencies in schizophrenic patients were significantly different from those in controls. Our results suggest that APOE alleles seem to be operative in the pathogenesis of schizophrenic disorders.
影响因子：
6.5
作者：
J. Hixson;D. T. Vernier
通讯作者：
J. Hixson;D. T. Vernier
影响因子：
6.5
作者：
V. Zannis;J. Breslow
通讯作者：
V. Zannis;J. Breslow