The Growth Factors: Potential Biomarkers and Therapeutic Targets in Kidney Diseases.
The Growth Factors: Potential Biomarkers and Therapeutic Targets in Kidney Diseases.
复制标题
生长因子：肾脏疾病的潜在生物标志物和治疗靶点。
DOI：
10.1159/000526208
复制
发表时间：
2022-11
期刊：
影响因子：
3.7
通讯作者：
Yi, Fan
中科院分区：
文献类型：
--
作者：
Tang, Wei;Zhang, Yufeng;Cui, Sijia;Yi, Fan
肾脏疾病是世界范围内普遍存在的健康问题。尽管在了解肾脏疾病的病理生理学方面已取得实质性进展，但目前尚无令人满意的临床治疗方法可用于预防或治疗肾脏疾病。因此，鼓励建立早期诊断、识别关键分子并开发新的治疗干预措施以减缓肾脏疾病的进展并减少其并发症的策略。生长因子在肾脏疾病的发展中起着至关重要的作用。生长因子水平的改变通常可以在病程中的循环和尿液中检测到。越来越多的研究表明，生长因子、受体和相关调节剂是用于诊断和/或预后的有前途的生物标志物以及治疗肾脏疾病的潜在治疗靶点。在这篇综述中，我们总结了生长因子在肾脏疾病诊断生物标志物和治疗靶点的潜在应用的最新进展，并强调了它们在临床试验中的表现。大多数针对生长因子的诊断和治疗策略距离临床实施还很遥远。对生长因子调节的病理生理学的更好理解和新干预方法的进展有望促进基于生长因子的肾脏疾病诊断和治疗的临床转化。
Kidney diseases are a prevalent health problem worldwide. Although substantial progress has been made in understanding the pathophysiology of kidney disease, currently there is no satisfactory clinical treatment available to prevent or treat kidney disease. Therefore, strategies to establish early diagnosis, identify the key molecules, and develop novel therapeutic interventions to slow the progression of kidney diseases and reduce their complications are encouraged. The growth factors play a crucial role in the development of kidney diseases. The altered levels of growth factors are usually detected in circulation and urine in the disease course. A growing body of studies has suggested that growth factors, receptors, and related regulators are promising biomarkers for the diagnosis and/or prognosis and potential therapeutic targets for the treatment of kidney diseases. In this review, we summarize recent advances in the potential applications of growth factors for diagnostic biomarkers and therapeutic targets in kidney diseases and highlight their performances in clinical trials. Most diagnostic and therapeutic strategies targeting growth factors are still far from clinical implementation. The better understanding of growth factor-regulated pathophysiology and the progress of new intervention approaches are expected to facilitate the clinical translation of growth factor-based diagnosis and therapy of kidney diseases.
登录
查看更多内容
影响因子：
6.2
作者：
Bromberg JS;Weir MR;Gaber AO;Yamin MA;Goldberg ID;Mayne TJ;Cal W;Cooper M
通讯作者：
Cooper M
影响因子：
158.5
作者：
Eremina, Vera;Jefferson, J. Ashley;Quaggin, Susan E.
通讯作者：
Quaggin, Susan E.
影响因子：
11.5
作者：
Hulse, Matthew;Rosner, Mitchell H.
通讯作者：
Rosner, Mitchell H.
影响因子：
16.2
作者：
Hellemons ME;Mazagova M;Gansevoort RT;Henning RH;de Zeeuw D;Bakker SJ;Lambers-Heerspink HJ;Deelman LE
通讯作者：
Deelman LE
影响因子：
19.6
作者：
通讯作者：
--