Different Periods of Periconceptional Undernutrition Have Different Effects on Growth, Metabolic and Endocrine Status in Fetal Sheep
Different Periods of Periconceptional Undernutrition Have Different Effects on Growth, Metabolic and Endocrine Status in Fetal Sheep
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DOI：
10.1203/pdr.0b013e3181bbde72
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发表时间：
2009-12-01
影响因子：
3.6
通讯作者：
Harding, Jane E.
中科院分区：
文献类型：
--
作者：
Rumball, Christopher W. H.;Bloomfield, Frank H.;Harding, Jane E.
围孕期营养不良会改变胎儿的生长和发育。然而，没有关于受孕前后营养不良的单独影响的数据，也没有关于潜在机制的数据。我们确定了轻度围孕期营养不良对妊娠晚期胎儿生长、葡萄糖-胰岛素轴以及母体和胎儿下丘脑-垂体-肾上腺轴的影响。与营养良好的对照组相比，母羊在受孕前 60 天、受孕后 30 天或两者均营养不良。受孕前营养不良会导致胎儿较小、生长缓慢，胎盘相对较大。交配前体重增加但交配后体重减轻的母羊，反之亦然，其胎儿最小。母羊的胎儿仅在受孕前出现营养不良，在使用仪器后生长速度更加缓慢，并且两个受孕前营养不良组的胎儿都随着母体禁食而减慢了生长速度。胎儿葡萄糖-胰岛素轴以及母体和胎儿下丘脑-垂体-肾上腺轴在各组之间没有差异。受孕前后不同时期的母亲营养不良对胎儿生长轨迹的影响不同，但在妊娠晚期的大小上并没有反映出来。仅孕前营养不良就会改变胎儿对妊娠晚期应激源的生长反应，这表明母体营养在这两个时期都很重要，并且胎儿的影响既不是仅仅由于底物限制，也不是由于营养不良时胎儿糖皮质激素暴露过多。 （儿科研究 66：605-613，2009 年）
Periconceptional undernutrition alters fetal growth and development. However, there are no data on separate effects of undernutrition before and after conception and few on underlying mechanisms. We determined the effects of mild periconceptional undernutrition on late gestation fetal growth, glucose-insulin axis, and maternal and fetal hypothalamic-pituitary-adrenal axes. Ewes were undernourished for 60 d before conception, 30 d after, or both, compared with well-nourished controls. Undernutrition before conception resulted in smaller, slower-growing fetuses with relatively larger placentae. Ewes that gained weight before, but lost weight after mating, or vice versa, had the smallest fetuses. Fetuses of ewes undernourished only before conception grew more slowly following instrumentation, and fetuses in both preconception undernutrition groups slowed their growth with a maternal fast. The fetal glucose-insulin axes and maternal and fetal hypothalamic-pituitary-adrenal axis were not different among groups. Maternal undernutrition at different periods around conception has different effects on fetal growth trajectory that are not reflected in size in late gestation. Preconceptional undernutrition alone alters fetal growth responses to late gestation stressors, suggesting that maternal nutrition is important at both times, and that fetal effects are neither due solely to substrate limitation, nor to excess fetal glucocorticoid exposure at the time of undernutrition. (Pediatr Res 66: 605-613, 2009)