Iodine-Catalyzed C–N Cleavage of Tertiary Amines: Synthesis of Methylene-Bridged Bis-1,3-dicarbonyl Compounds
Iodine-Catalyzed C–N Cleavage of Tertiary Amines: Synthesis of Methylene-Bridged Bis-1,3-dicarbonyl Compounds
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DOI：
10.1055/s-0034-1378208
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发表时间：
2014-06
期刊：
影响因子：
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通讯作者：
Lin Lu;Shengmei Guo;Qiheng Xiong;Shengyi Liu;Xiang Li;H. Cai
中科院分区：
文献类型：
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作者：
Lin Lu;Shengmei Guo;Qiheng Xiong;Shengyi Liu;Xiang Li;H. Cai
摘要描述了一种新的、高效的碘催化叔胺的C-N裂解反应，该反应通过sp3 C-H键氧化偶联反应进行。利用环境友好的催化体系，与1,3-二羰基化合物结合，合成了多种亚甲基桥接的双-1,3-二羰基化合物，产率高达92%。
Abstract A novel and efficient iodine-catalyzed C–N cleavage of tertiary amines via an sp3 C–H bond oxidative coupling reaction is described. A wide range of methylene-bridged bis-1,3-dicarbonyl compounds were synthesized in up to 92% yield by using an environmentally benign catalytic system in combination with 1,3-dicarbonyl compounds.