Upper cervical myelopathy in achondroplasia.
Upper cervical myelopathy in achondroplasia.
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软骨发育不全中的上颈椎脊髓病。
DOI：
10.1093/ajcp/68.1.68
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发表时间：
1977
影响因子：
3.5
通讯作者：
J. Bernstein
中科院分区：
文献类型：
--
作者：
S. Samuel Yang;D. P. Corbett;A. Joseph Brough;K. Heidelberger;J. Bernstein
2例软骨增生症婴儿的枕大孔较小，相应的上颈髓受到致死性压迫。这种损伤在组织学上与过度伸展型脊髓损伤相似。两例中的一例显示枕大孔前移。移位被认为值得进一步验证，因为它可能是脊髓过度伸展损伤易感性的另一个因素。第二例患者存活了6个月，表明并非所有的高位颈髓损伤都是立即致命的。有亚致命性损伤的患者有可能通过手术挽救。据推测，在软骨发育不全的情况下，可能有更多的非致命性上颈脊髓损伤，特别是在婴儿无法直立头部的早期。上颈髓轻微损伤的真实发生率尚不清楚，尽管目前认为这种情况很少见。根据这两个病例的研究结果，建议尽可能避免头部过度伸展。
Two achondroplastic infants had small foramina magna with lethal compression of the corresponding upper cervical spinal cords. The damage was histologically comparable to the hyperextension type of spinal cord injury. An anterior displacement of the foramen magnum was demonstrated in one of the two cases. The displacement is considered worthy of future verification as it may be an additional factor in susceptibility to hyperextension injury to the spinal cord. The second patient survived 6 months, demonstrating that not all upper cervical spinal cord injuries are immediately fatal. Patients who have sublethal lesions are potentially salvageable by surgery. It is also speculated that there might be more cases of nonlethal upper cervical spinal-cord damage in achondroplasia, especially in early infancy when infants are unable to hold their heads erect. The true incidence of slight upper cervical spinal cord damage is not known, although it is considered rare at present. As a result of the findings in these two cases, it is suggested that hyperextension of the head be avoided, when possible.