EVIDENCE FOR THE EARLY PRENATAL DEVELOPMENT OF CORTICAL CHOLINERGIC AFFERENTS FROM THE NUCLEUS OF MEYNERT IN THE HUMAN-FETUS
EVIDENCE FOR THE EARLY PRENATAL DEVELOPMENT OF CORTICAL CHOLINERGIC AFFERENTS FROM THE NUCLEUS OF MEYNERT IN THE HUMAN-FETUS
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DOI：
10.1016/0304-3940(85)90406-9
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发表时间：
1985-01-01
影响因子：
2.5
通讯作者：
EDWARDSON, JA
中科院分区：
文献类型：
--
作者：
CANDY, JM;PERRY, EK;EDWARDSON, JA
一项结合组织化学和生物化学方法的研究表明，在人类胎儿妊娠的前3个月，命名物质Meynert区核的胆碱能系统在组织化学和神经化学上都有很好的定义。因此，在发育12至22周之间，在Meynert细胞核的神经节、细胞体和过程中观察到最强烈的乙酰氯胺酯酶（AChE）组织化学反应。观察到从Meynert核到皮质地幔的疼痛染色纤维，并且在地幔内也存在疼痛染色纤维。Meynert核内的微穿孔样品含有比包括纹状体在内的任何其他检查区域更高水平的胆碱乙酰转移酶（ChAT）活性，而在皮层地幔中，ChAT活性水平与成人大脑皮层中的水平相当。这些观察结果表明，来自meynert核的胆碱能神经支配-被认为是成人大脑皮层胆碱能传入事件的主要来源-可能在人类新皮层的早期发育中起关键作用。
A combined histochemical and biochemical approach has shown that the cholinergic system in the nucleus of Meynert region of the substantia innominata is well defined both histochemically and neurochemically within the first 3 months of gestation in the human foetus. Thus, at between 12 and 22 weeks of development the most intense acetylchlinesterase (AChE) histochemical reactivity was observed in the neuropil, cell bodies and processes in the nucleus of Meynert. AChE-stained fibres were observed which coursed from the nucleus of Meynert towards the cortical mantle and within the mantle AChE-stained fibres were also present. Micropunch samples from within the nucleus of Meynert contained higher levels of choline acetyltransferase (ChAT) activity than any other area examined including the striatum, while in the cortical mantle the level of ChAT activity was comparable to that found in the adult cerebral cortex. These observations suggest that the cholinergic innervation from the nucleus of Meynert-considered to be the major source of cholinergic afferents in the adult cerebral cortex-may play a key role in the early development of the human neocortex.