The Association of Intracranial Vascular Calcification and Stenosis With Acute Ischemic Cerebrovascular Events
The Association of Intracranial Vascular Calcification and Stenosis With Acute Ischemic Cerebrovascular Events
复制标题
DOI：
10.1097/rct.0000000000000629
复制
发表时间：
2017-11-01
影响因子：
1.3
通讯作者：
Mossa-Basha, Mahmud
中科院分区：
文献类型：
--
作者：
Quiney, Brendan;Ying, Stephen M.;Mossa-Basha, Mahmud
目的探讨颅内动脉钙化（IAC）与急性下游缺血性卒中（dAIS）/短暂性脑缺血发作（TIA）的关系，同时考虑狭窄因素。2名神经放射科医生记录了每支血管的IAC和大于或等于30%的狭窄。钙化和dAIS之间的关联进行了评估，采用多元逻辑回归，控制传统的危险因素和stenosis.Results共1287动脉段99例患者进行了审查。颅内动脉钙化与dAIS显著相关（比值比[OR]，2.2; P = 0.009）。这种相关性在非狭窄动脉中持续存在，具有IAC的动脉发生dAIS的可能性显著高于不具有IAC的动脉（OR，2.5; P = 0.009）。然而，在狭窄动脉中，钙化狭窄与dAIS的相关性低于非钙化狭窄（OR，0.55; 95%可信区间，0.17-1.8; P = 0.33）。当存在狭窄时，IAC不会增加与dAIS的关联。如组织学文献所示，狭窄性和非狭窄性钙化可能代表不同的疾病过程。
Objective The aim of this article was to evaluate the association of intracranial artery calcification (IAC) with acute downstream ischemic stroke (dAIS)/transient ischemic attack while considering stenosis.Methods Consecutive stroke computed tomography angiography head/neck examinations from January 2010 to April 2010 were reviewed. Per-vessel IAC and stenosis of greater than or equal to 30% were documented by 2 neuroradiologists. Associations between calcification and dAIS were assessed using multivariate logistic regression, controlling for traditional risk factors and stenosis.Results A total of 1287 arterial segments from 99 patients were reviewed. Intracranial artery calcification was significantly associated with dAIS (odds ratio [OR], 2.2; P = 0.009). This association persisted among nonstenotic arteries, with significantly higher likelihood of dAIS for arteries with IAC than those without (OR, 2.5; P = 0.009). However, among stenotic arteries, calcified stenoses had a lower association of dAIS than noncalcified stenoses (OR, 0.55; 95% confidence interval, 0.17-1.8; P = 0.33).Conclusions Without concurrent stenosis, IAC is a significant risk factor for dAIS. When stenosis is present, IAC does not increase the association with dAIS. Stenotic and nonstenotic calcifications may represent different disease processes, as represented in the histology literature.