PREFERENTIAL REPRESENTATION OF THE FOVEA IN THE PRIMARY VISUAL-CORTEX
PREFERENTIAL REPRESENTATION OF THE FOVEA IN THE PRIMARY VISUAL-CORTEX
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DOI：
10.1038/361719a0
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发表时间：
1993-02-25
期刊：
影响因子：
64.8
通讯作者：
COWEY, A
中科院分区：
文献类型：
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作者：
AZZOPARDI, P;COWEY, A
视网膜中央凹，相当于视觉的中心程度，在视觉皮层中的空间表现过度。它约占视网膜面积的0.01%，但至少占纹状皮质的8% 1 -3。这是否仅仅反映了视网膜中神经节细胞的不均匀分布4 -7，或者中央凹的皮质代表优先扩展8 -13？答案取决于视网膜和皮层放大因子之间长期存在的差异的解决方案。我们以不同的方式处理这个问题，使用从皮层到视网膜的逆行跨神经元示踪剂，直接将投射到纹状皮层标记区域的神经节细胞的数量联系起来。我们在这里报告，中央凹附近的神经节细胞分配的皮质组织比周边的3.3至5.9倍，并得出结论，最中央视网膜的皮质代表性比预期的神经节细胞的密度大得多。
THE retinal fovea, which corresponds to the central degree or so of vision, is spatially over-represented in the visual cortex. It is about 0.01% of retina area, but at least 8% of the striate cortex1-3. Does this simply reflect an equivalently uneven distribution of ganglion cells in the retina4-7, or is the cortical representation of the fovea preferentially expanded8-13? The answer hinges on the resolution of long-standing discrepancies between the retinal and cortical magnification factors. We approached the problem in a different way, using a retrograde transneuronal tracer from cortex to retina to relate directly the number of ganglion cells projecting to marked areas of striate cortex. We report here that ganglion cells near the fovea were allocated 3.3 to 5.9 times more cortical tissue than more peripheral ones, and conclude that the cortical representation of the most central retina is much greater than expected from the density of its ganglion cells.