Brain atrophy in long-term abstinent alcoholics who demonstrate impairment on a simulated gambling task
Brain atrophy in long-term abstinent alcoholics who demonstrate impairment on a simulated gambling task
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DOI：
10.1016/j.neuroimage.2006.06.013
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发表时间：
2006-09-01
期刊：
影响因子：
5.7
通讯作者：
Moon, Kirk
中科院分区：
文献类型：
--
作者：
Fein, George;Landman, Bennett;Moon, Kirk
我们最近在长期戒酒者(AbsAlc)的模拟赌博任务(SGT)上发现了损害。已被证明对完整的SGT表现是必要的大脑区域是腹内侧额前皮质(VMPFC)和杏仁核；VMPFC或杏仁核受损的患者表现出类似于物质滥用人群的SGT损害。我们使用基于体素的形态计量学(VBM)检查了101名参与者的T1加权磁共振成像的这些大脑区域。使用我们开发的改进[Fein，G.，Landman，B.，Tran，H.，Barakos，J.，Moon，K.，Di Sclafani，V.，Shumway，R.，2006]进行VBM。大脑形态的统计参数图：通过使用大脑提取的图像作为输入，敏感度显著提高。[Baron，J.C.，Chetelat，G.，Desgranges，B.，Perchey，G.，Landeau，B.，De la Sayette，V.，Eustache，F.，2001。用基于体素的形态计量学对轻度阿尔茨海默病患者灰质丢失的活体测绘。NeuroImage 14(2)，298309]，其中我们使用头骨剥离的图像作为输入。我们还将分析限制在由Talairach Daemon资源定义的杏仁核和VMPFC组成的ROI上。与对照组相比，AbsAlc参与者杏仁核内灰质密度显著降低。因此，SGT决策缺陷与杏仁核灰质减少有关，杏仁核是大脑的一个区域，以前在神经样本中涉及类似的决策障碍。这种结构上的异常可能是长期酗酒或依赖的结果，也可能反映了一种预先存在的因素，使人容易患上严重的酒精中毒。从图像分析的角度来看，这项工作证明了使用颅骨剥离输入和将分析限制在ROI上所产生的更高的敏感度。如果没有这两个方法学上的进步，这项工作就不会有统计上的重大发现。(C)2006 Elsevier Inc.保留所有权利。
We recently demonstrated impairment on the Simulated Gambling Task (SGT) in long-term abstinent alcoholics (AbsAlc). Brain regions that have been shown to be necessary for intact SGT performance are the ventromedial prefrontal cortex (VMPFC) and the amygdala; patients with VMPFC or amygdalar damage demonstrate SGT impairments similar to those of substance abusing populations. We examined these brain regions, using T1-weighted MRIs, in the 101 participants from our previous study using voxel-based morphometry (VBM). VBM was performed using a modification we developed [Fein, G., Landman, B., Tran, H., Barakos, J., Moon, K., Di Sclafani, V., Shumway, R., 2006. Statistical parametric mapping of brain morphology: sensitivity is dramatically increased by using brain-extracted images as inputs. Neuroimage] of Baron's procedure, [Baron, J.C., Chetelat, G., Desgranges, B., Perchey, G., Landeau, B., de la Sayette, V., Eustache, F., 2001. In vivo mapping of gray matter loss with voxel-based morphometry in mild Alzheimer's disease. Neuroimage 14 (2), 298309], in which we use skull-stripped images as input. We also restricted the analysis to a ROI consisting of the amygdala and VMPFC as defined by the Talairach Daemon resource. Compared to the controls, the AbsAlc participants had significant foci of reduced gray matter density within the amygdala. Thus, SGT decision-making deficits are associated with reduced gray matter in the amygdala, a brain region previously implicated in similar decision-making impairments in neurological samples. This structurally based abnormality may be the result of long-term alcohol abuse or dependence, or it may reflect a pre-existing factor that predisposes one to severe alcoholism. From an image analysis perspective, this work demonstrates the increased sensitivity that results from using skull-stripped inputs and from restricting the analysis to a ROI. Without both of these methodological advances, no statistically significant finding would have been forthcoming from this work. (c) 2006 Elsevier Inc. All rights reserved.