PEYERS PATCH-SPECIFIC LYMPHOCYTE HOMING RECEPTORS CONSIST OF A VLA-4-LIKE ALPHA-CHAIN ASSOCIATED WITH EITHER OF 2 INTEGRIN BETA-CHAINS, ONE OF WHICH IS NOVEL
PEYERS PATCH-SPECIFIC LYMPHOCYTE HOMING RECEPTORS CONSIST OF A VLA-4-LIKE ALPHA-CHAIN ASSOCIATED WITH EITHER OF 2 INTEGRIN BETA-CHAINS, ONE OF WHICH IS NOVEL
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DOI：
10.1002/j.1460-2075.1989.tb03566.x
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发表时间：
1989-06-01
期刊：
影响因子：
11.4
通讯作者：
WEISSMAN, IL
中科院分区：
文献类型：
--
作者：
HOLZMANN, B;WEISSMAN, IL
Lymphocytes home to various lymphoid organs by adhering to and migrating through specialized high endothelial venules (HEV). The murine cell surface heterodimer LPAM-1 is involved in the homing of lymphocytes to mucosal sites (Peyer''s patches). LPAM-1 has an .alpha. subunit (.alpha.4m) analogous to the .alpha. chain of the human integrin molecule VLA-4. Here we show that the LPAM-1 .beta. subunit (.beta.P) is immunochemically and biochemically distinct from previously defined integrin .beta. subunits, suggesting that .BETA.P represents a novel integrin .beta. subunit. Depending on the cellular source two alternative .beta. subunits, .beta.P and integrin .beta.1, can be isolated in association with .alpha.4m. Therefore, .alpha.4m is the common subunit of the unique integrin LPAM-1 (.alpha.4m.beta.P) and of the heterodimer LPAM-2 (.alpha.4m.beta.1), which is analogous to VLA-4. Antibody-blocking experiments suggest that, in additin to LPAM-1, LPAM-2 is also involved in the organ-specific adhesion of lymphocytes to Peyer''s patch HEV.
