TISSUE-SPECIFIC REGULATION OF LIPOPROTEIN-LIPASE ACTIVITY BY INSULIN GLUCOSE IN NORMAL-WEIGHT HUMANS
TISSUE-SPECIFIC REGULATION OF LIPOPROTEIN-LIPASE ACTIVITY BY INSULIN GLUCOSE IN NORMAL-WEIGHT HUMANS
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DOI：
10.1016/0026-0495(91)90178-y
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发表时间：
1991-02-01
影响因子：
9.8
通讯作者：
ECKEL, RH
中科院分区：
文献类型：
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作者：
FARESE, RV;YOST, TJ;ECKEL, RH
研究了8名正常体重受试者（4名男性，4名女性），以确定脂肪组织（ATLPL）和股外侧肌骨骼肌（SMLPL）中脂蛋白脂肪酶（LPL）的相对活性，无论是在空腹状态下还是在6小时胰岛素/葡萄糖输注后。ATLPL和SMLPL的平均空腹水平无统计学差异。胰岛素/葡萄糖输注6小时后，平均ATLPL活性显著高于空腹水平（P<0.01），而平均SMLPL活性较基础水平下降（P<0.05）。LPL反应性的这些组织特异性变化（0至6小时）显著不同（P<0.01）。没有观察到男女之间的差异。这些不同的组织特异性LPL对胰岛素/葡萄糖的反应将用于引导脂蛋白胆固醇衍生的脂肪酸远离肌肉并转移到脂肪组织进行储存。
Eight normal-weight subjects (four men, four women) were studied to determine the relative activities of lipoprotein lipase (LPL) in adipose tissue (ATLPL) and vastus lateralis skeletal muscle (SMLPL), both in the fasting state and in response to a 6-hour insulin/glucose infusion. Mean fasting levels of ATLPL and SMLPL were not statistically different. After 6 hours of insulin/glucose infusion, mean ATLPL activity was significantly greater than the fasting level (P< .01), while mean SMLPL activity decreased from basal (P< .05). These tissue-specific changes in LPL responsiveness (0 to 6 hours) were significantly different (P< .01). No differences between men and women were observed. These divergent tissue-specific LPL responses to insulin/glucose would serve to direct lipoprotein triglyceride-derived fatty acids away from muscle and to adipose tissue for storage.