ALLOGENEIC POLYMORPHISM AND ALLOIMMUNE MEMORY IN THE CORAL, MONTIPORA-VERRUCOSA
ALLOGENEIC POLYMORPHISM AND ALLOIMMUNE MEMORY IN THE CORAL, MONTIPORA-VERRUCOSA
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DOI：
10.1097/00007890-198010000-00012
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发表时间：
1980-01-01
期刊：
影响因子：
6.2
通讯作者：
JOHNSTON, IS
中科院分区：
文献类型：
--
作者：
HILDEMANN, WH;JOKIEL, PL;JOHNSTON, IS
珊瑚M.疣孢无一例外地在890个不同配对的菌落（克隆）中表现出非常广泛的异源多态性。超过1400互惠组织不相容性，实际上记录，因为双边细胞毒性之间观察到的大多数异源寄生虫测试。个体在细胞表面组织相容性（H）标记方面的独特性表现在从强到中等到弱的可能不相容性的整个谱中。定向性、严重性和排斥率主要由克隆间寄生虫的遗传组成决定。同种异体移植反应时间密切依赖于温度和负相关的H屏障的强度。增强的同种异体免疫或早期记忆仅在预致敏后2天即可证实，并在4-8天后达到最大。延长初次免疫后，强有力的同种免疫记忆持续4周，但在8-16周后消失。因此，珊瑚的免疫排斥性可能反映在脊椎动物缺乏长期记忆。
Populations of the coral M. verrucosa exhibited very extensive allogeneic polymorphism revealed by parabiotic incompatibility among 890 different pairings of colonies (clones) without exception. More than 1400 reciprocal histoincompatibilities were actually recorded because bilateral cytotoxicity was observed among most of the alloparabionts tested. This uniqueness of the individual in terms of cell surface histocompatibility (H) markers is manifest in the whole spectrum of possible incompatibilities from strong to moderate to weak. The directionality, severity and rejection rate were mainly determined by the genetic constitutions of the interclonal parabionts. Allograft reaction times were closely temperature dependent and inversely related to the strength of the H barrier. Heightened alloimmunity or early memory was demonstrable after only 2 days of presensitization and became maximal after 4-8 days. After prolonged primary immunization, potent alloimmune memory persisted for 4 wk, but disappeared after 8-16 wk. Immunological primitiveness in corals may therefore be reflected in the lack of long-lived memory as found among vertebrates.