Prognostic factors for squamous cell carcinoma of the temporal bone: extensive bone involvement or extensive soft tissue involvement?
Prognostic factors for squamous cell carcinoma of the temporal bone: extensive bone involvement or extensive soft tissue involvement?
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DOI：
10.3109/00016480802642096
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发表时间：
2009-11-01
影响因子：
1.4
通讯作者：
Yoshizaki, Tomokazu
中科院分区：
文献类型：
--
作者：
Ito, Makoto;Hatano, Miyako;Yoshizaki, Tomokazu
结论：广泛的骨侵蚀与颞骨鳞状细胞癌（SCC）的预后较差相关，但广泛的软组织累及与预后无关。肿瘤的可切除性似乎是影响颞骨鳞状细胞癌预后的主要因素。目的：探讨颞骨鳞状细胞癌的预后因素，包括首发临床症状和影像学表现。患者与方法：对外耳道（EAC）或中耳（ME）原发性鳞状细胞癌患者的临床症状进行回顾性分析。使用改进的匹兹堡分类分析临床症状与癌症严重程度分期的相关性，以及疾病特异性生存（DSS）。结果：16例EAC （n = 13）或ME （n = 3）的原发性SCC患者被纳入研究人群。在第一次医学检查时是否发现听力障碍或耳痛对DSS没有影响。影像学检查发现骨受累范围扩大与预后不良显著相关（p < 0.05）。无广泛骨侵蚀的患者预后良好，广泛（>= 0.5 cm）的软组织受损伤与预后无关。未行骨切除或未行手术的患者预后差（p < 0.01）。
Conclusion: Extensive bone erosion correlated with a worse prognosis of the squamous cell carcinoma (SCC) of the temporal bone but extensive soft tissue involvement did not correlate with prognosis in this study. Resectability of the tumor seems to be major prognostic factor of temporal bone SCC. Objective: Prognostic factors for SCC of the temporal bone were evaluated regarding initial clinical symptoms and radiographic imaging. Patients and methods: Clinical symptoms of the patients with primary SCC of the external auditory canal (EAC) or middle ear (ME) were reviewed based on medical records. Correlation of clinical symptoms and cancer severity staging using the modified Pittsburgh classification was analyzed, along with disease-specific survival (DSS). Results: Sixteen patients with primary SCC of the EAC (n = 13) or ME (n = 3) were included in the study population. DSS was not influenced by whether a hearing disturbance or otalgia was noted at the first medical examination. Extended bone involvement identified with imaging studies significantly correlated with worse prognosis (p < 0.05). Prognoses of patients without extensive bone erosion were good, and extensive (>= 0.5 cm) soft tissue involvement did not correlate with prognosis in this study. Prognoses of patients with insufficient bone resection or no surgery were significantly poor (p < 0.01).