Congenital-nevus-like nevi, nevi spili, and café-au-lait spots in patients with malignant melanoma.
Congenital-nevus-like nevi, nevi spili, and café-au-lait spots in patients with malignant melanoma.
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恶性黑色素瘤患者的先天性痣样痣、斑点痣和牛奶咖啡斑。
DOI：
10.1111/j.1524-4725.1985.tb03005.x
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Marcia S. Levenstein
中科院分区：
文献类型：
--
作者：
A. W. Kopf;L. Levine;Darrell S. Rigel;Robert J. Friedman;Marcia S. Levenstein
将105名成年恶性黑色素瘤（MM）患者的先天性痣样痣（CNLN）患病率与601名未患MM的对照组进行比较。两组患者均进行了全身皮肤检查。对照组患者表现出除色素病变外的其他症状。在本系列中，10例（9.5%）MM组临床诊断CNLN直径大于1.5 cm。这些CNLN与MM位点不相邻。MM组的CNLN患病率为9.5%，显著高于对照组的2.5% （p < 0.005）。两组患者均无较大先天性坏死痣（大于等于20cm）。此外，在MM组中，有5例（4.8%）患者有nevi spili (NS)， 13例（12.4%）患者有cafei -au-lait spots （CLS）。这两种色素病变的患病率与非黑色素瘤对照组的患病率无显著差异（NS为2.3%，CLS为13.8%）。与没有CNLN的人相比，CNLN患者发生MM的相对风险为4.1，这表明这些痣可能是易于发生恶性黑色素瘤的个体的标志。
The prevalence of congenital-nevus-like nevi (CNLN) in a group of 105 adults who had malignant melanoma (MM) was compared with that in a control group of 601 adults not afflicted by MM. Total cutaneous examinations were performed on both groups. The control group presented with complaints other than pigmented lesions. In this series, 10 (9.5%) of the group with MM had clinically diagnosed CNLN 1.5 cm or larger in diameter. These CNLN were not in contiguity with the MM sites. The 9.5% prevalence of CNLN in the group with MM was significantly higher (p less than 0.005) than the 2.5% CNLN observed in the control population. None of the patients in either group had large congenital nevocytic nevi (greater than or equal to 20 cm). In addition, in the group with MM, 5 patients (4.8%) had nevi spili (NS) and 13 (12.4%) had café-au-lait spots (CLS). The prevalence rates for these two types of pigmented lesions were not significantly different from those observed in the nonmelanoma control group (2.3% for NS; 13.8% for CLS). The relative risk for developing MM is 4.1 in people with CNLN compared with those without CNLN, which indicates that these nevi may be markers for individuals prone to develop malignant melanoma.
影响因子：
3.3
作者：
CLARK, WH;ELDER, DE;VANHORN, M
通讯作者：
VANHORN, M