Pleiotropic effects of CXC chemokines in gastric carcinoma:: differences in CXCL8 and CXCL1 expression between diffuse and intestinal types of gastric carcinoma
Pleiotropic effects of CXC chemokines in gastric carcinoma:: differences in CXCL8 and CXCL1 expression between diffuse and intestinal types of gastric carcinoma
复制标题
DOI：
10.1111/j.1365-2249.2003.02305.x
复制
发表时间：
2003-12-01
影响因子：
4.6
通讯作者：
Müller-Hermelink, HK
中科院分区：
文献类型：
--
作者：
Eck, M;Schmausser, B;Müller-Hermelink, HK
CXC趋化因子调节宿主免疫、新血管形成、肿瘤生长和侵袭行为。尽管它们在肿瘤生物学中的相关性，肠型和弥漫型胃癌，表现出完全不同的生长模式，趋化因子的表达还没有被详细研究。在这项研究中，CXC趋化因子CXCL 8 [白细胞介素（IL）-8]，CXCL 1 [生长相关癌基因α（Groalpha）]，CXCL 9 [干扰素（IFN）-γ诱导的单核细胞因子]和CXCL 10 [IFN-γ诱导蛋白-10（IP-10）]和相应的趋化因子受体CXCR 1 -3的表达在肠型和弥漫型胃癌中进行了研究。所有患者的肿瘤细胞均表达CXCL 8。CXCL 8在弥漫型胃癌中的表达明显强于浸润型胃癌（P
CXC chemokines modulate host immunity, neovascularization, growth and invasive behaviour of tumours. Despite their relevance in tumour biology, chemokine expression in intestinal- and diffuse-type gastric carcinoma, which exhibit a completely different growth pattern, has not been investigated in detail. In this study, expression of the CXC chemokines CXCL8 [interleukin (IL)-8], CXCL1 [growth-related oncogene alpha (Groalpha)], CXCL9 [monokine induced by interferon (IFN)-gamma] and CXCL10 [IFN-gamma-inducible protein-10 (IP-10)] and the corresponding chemokine receptors CXCR1-3 was investigated by immunohistochemistry in intestinal- and diffuse-type gastric carcinoma. Tumour cells of all patients expressed CXCL8. CXCL8 expression was significantly stronger in tumour cells of diffuse- rather than intestinal-type gastric carcinoma (P