A NEW PRINCIPLE OF RNA FOLDING BASED ON PSEUDOKNOTTING
A NEW PRINCIPLE OF RNA FOLDING BASED ON PSEUDOKNOTTING
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DOI：
10.1093/nar/13.5.1717
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发表时间：
1985-01-01
影响因子：
14.9
通讯作者：
BOSCH, L
中科院分区：
文献类型：
--
作者：
PLEIJ, CWA;RIETVELD, K;BOSCH, L
涉及发夹或RNA内部环的三级相互作用可导致扩展的准连续双螺旋茎区，由双工RNA的同轴堆叠片段组成，由单链连接桥接。这种类型的紧凑折叠在RNA分子的各种战略区域发挥作用。讨论了它们在核糖体功能、RNA剪接和trna样结构识别中的作用。
Tertiary interactions involving hairpin or interior loops of RNA can lead to extended quasi-continuous double helical stem regions, consisting of coaxially stacked segments of duplex RNA, bridged by single-stranded connections. This type of compact folding plays a role in various strategic regions of RNA molecules. Their role in ribosome functioning, RNA splicing and recognition of tRNA-like structures is discussed.