PERICARDIAL ADAPTATIONS DURING CHRONIC CARDIAC DILATION IN DOGS
PERICARDIAL ADAPTATIONS DURING CHRONIC CARDIAC DILATION IN DOGS
复制标题
DOI：
10.1161/01.res.54.3.294
复制
发表时间：
1984-01-01
影响因子：
20.1
通讯作者：
LEWINTER, MM
中科院分区：
文献类型：
--
作者：
FREEMAN, GL;LEWINTER, MM
心包适应慢性心脏扩张的方式尚不清楚。最近的工作间接表明，心包的大小和/或其压力容积关系的慢性心脏扩大改变。为了进一步研究这个问题，比较了7只正常犬和7只因系统性动静脉瘘导致慢性容量超负荷肥大的犬的心包压力-容量和应力-应变关系、表面积、质量和平均厚度。具有显著心脏肥大的犬在任何压力下均具有增加的心包体积，并且通过非线性回归分析确定整个曲线的斜率的比例常数。这与心包表面积和质量平行增加相关，因此平均厚度不变。应力应变分析的数据表明，心包的机械性能没有显着差异，在狗与慢性心脏扩张。在慢性心脏扩张过程中，心包明显增大。心包腔顺应性更好，尽管心包的固有硬度似乎没有变化。此外，由于心包质量增加，对慢性扩张的反应似乎也涉及新的心包组织的增加。
The manner in which the pericardium adapts to chronic cardiac dilation is not known. Recent work indirectly suggested that the size of the pericardium and/or its pressure volume relation was altered by chronic cardiac enlargement. To examine this question further, pericardial pressure-volume and stress-strain relations, surface area, mass and average thickness were compared in 7 normal dogs and 7 with chronic volume overload hypertrophy due to a systemic arteriovenous fistula. Dogs with significant cardiac hypertrophy had an increased pericardial volume at any pressure and a proportionally constant for the slope of the entire curve as determined by nonlinear regression analysis. This was associated with parallel increases in pericardial surface area and mass such that average thickness was unchanged. Stress-strain analysis of the data revealed that the mechanical properties of the pericardium were not significantly different in dogs with chronic cardiac dilation. During chronic cardiac dilation the pericardium evidently enlarges in size and mass. The pericardial chamber is more compliant, although the intrinsic stiffness of the pericardium appears to be unchanged. Further, since pericardial mass is increased, the response to chronic dilation appears to also involve the addition of new pericardial tissue.