Microwave Specific Effect on Catalytic Enantioselective Conia-Ene Reaction
Microwave Specific Effect on Catalytic Enantioselective Conia-Ene Reaction
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DOI：
10.1246/cl.160200
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发表时间：
2016-06-05
影响因子：
1.6
通讯作者：
Yamada, Tohru
中科院分区：
文献类型：
--
作者：
Tashima, Shigeki;Sawada, Taichi;Yamada, Tohru
采用微波辐射法研究了Cu（OTf）（2）与手性胺的不对称反应。在严格控制温度的条件下，微波辐射提高了化学产率，而没有任何对映选择性的损失。因此，通过微波照射的动力学速率是通过常规加热的动力学速率的1.15倍。这些观察结果表明，微波的特定效应提高了对映选择性Conia烯反应的效率。
Microwave irradiation was applied to the enantioselective Conia-ene reaction catalyzed by Cu(OTf)(2) with a chiral amine. Under strictly controlled temperature conditions, microwave irradiation improved the chemical yields without any loss of the enantioselectivities. Consequently, the kinetic rate by the microwave irradiation was 1.15 times higher than that by conventional heating. These observations suggested that the microwave specific effects enhanced the efficiency of the enantioselective Conia-ene reaction.