Coincidence of genetic loci for plasma cholesterol levels and obesity in a multifactorial mouse model.
Coincidence of genetic loci for plasma cholesterol levels and obesity in a multifactorial mouse model.
复制标题
多因素小鼠模型中血浆胆固醇水平和肥胖的遗传位点的一致性。
DOI：
10.1172/jci116649
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Lusis,AJ
中科院分区：
文献类型：
--
作者：
Warden,CH;Fisler,JS;Pace,MJ;Svenson,KL;Lusis,AJ
我们检测了小白鼠与C57BL/6J杂交的回交后代，其屠体脂肪含量为1-50%(n=215)，血浆总胆固醇含量为22-130 mg/dl(n=238)。统计分析显示，小鼠远端7号染色体与血浆总胆固醇(几率[LOD]5.8)和屠体脂肪(LOD 3.8)显示出显著的连锁关系。6号染色体上的一个基因座也与血浆总胆固醇(LOD 5.6)显著相关，但与屠体脂肪无关。这两个染色体区域都不包含任何可能影响脂蛋白代谢的先前定位的基因，这表明已经确定了影响血浆脂蛋白水平的新的遗传因素。
We have examined backcross progeny derived from a cross of Mus spretus with C57BL/6J, that range from 1 to 50% carcass lipid (n = 215), and from 22 to 130 mg/dl plasma total cholesterol (n = 238). Statistical analysis revealed that distal mouse chromosome 7 exhibits significant linkage both to plasma total cholesterol (likelihood of the odds [LOD] 5.8) and to carcass lipid (LOD 3.8). A locus on chromosome 6 also shows significant linkage to plasma total cholesterol (LOD 5.6), but no linkage to carcass lipid. Neither chromosomal region contains any previously mapped genes likely to influence lipoprotein metabolism, indicating that novel genetic factors contributing to plasma lipoprotein levels have been identified.