Low seroprevalence of IgG antibodies to Ebola virus in an epidemic zone: Ogooue-Ivindo region, northeastern Gabon, 1997
Low seroprevalence of IgG antibodies to Ebola virus in an epidemic zone: Ogooue-Ivindo region, northeastern Gabon, 1997
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DOI：
10.1086/427994
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发表时间：
2005-03-15
影响因子：
6.4
通讯作者：
Ryder, RW
中科院分区：
文献类型：
--
作者：
Heffernan, RT;Pambo, B;Ryder, RW
进行了一项以人群为基础的血清学调查，以确定埃博拉病毒（EBO）抗体的血清阳性率在一个地区，经历了多次流行的EBO出血热。用酶联免疫吸附试验（ELISA）检测了8个村2533名居民血清中的埃博拉病毒（EBO-Z）免疫球蛋白（IG）G和IgM抗体，阳性率为38.6%。14份样本（1.4%）被发现IgG抗体阳性，其中4份（0.4%）是EBO出血热流行的幸存者样本。基于其余10名无EBO暴露史的IgG血清阳性个体的血清阳性率为1.0%（精确二项式95%置信区间，0.5%-1.9%）。未发现血清标本中EBO-Z病毒IgM抗体阳性。低血清阳性率表明，在公认的疫情之外，该流行区的人暴露于EB病毒是罕见的。
A population-based serosurvey was performed to determine the seroprevalence of antibodies to Ebola virus (EBO) in a region that has experienced multiple epidemics of EBO hemorrhagic fever. Of 2533 residents in 8 villages, serum samples from 979 (38.6%) were tested by enzyme-linked immunosorbent assay for immunoglobulin (Ig) G and IgM antibodies to Ebola-Zaire (EBO-Z) virus. Fourteen samples (1.4%) were found positive for IgG antibodies, and 4 of these (.4%) were samples from survivors of an epidemic of EBO hemorrhagic fever. Seroprevalence based on the remaining 10 IgG-sero-positive individuals with no history of exposure to EBO was 1.0% (exact binomial 95% confidence interval, 0.5%-1.9%). No serum samples were found positive for IgM antibodies to EBO-Z virus. The low seroprevalence suggests that, outside of recognized outbreaks, human exposure to EBO in this epidemic zone is rare.